Abstract
| Original language | English |
|---|---|
| Pages (from-to) | 430 - 444 |
| Number of pages | 15 |
| Journal | Physics in Medicine and Biology |
| Volume | 61 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - 2016 |
Cite this
}
A radiobiology-based inverse treatment planning method for optimisation of permanent l-125 prostate implants in focal brachytherapy. / Haworth, Annette; Mears, Christopher ; Betts, John M; Reynolds, Hayley M; Tack, Guido; Leo, Kevin; Williams, Scott Garrick; Ebert, Martin A.
In: Physics in Medicine and Biology, Vol. 61, No. 1, 2016, p. 430 - 444.Research output: Contribution to journal › Article › Research › peer-review
TY - JOUR
T1 - A radiobiology-based inverse treatment planning method for optimisation of permanent l-125 prostate implants in focal brachytherapy
AU - Haworth, Annette
AU - Mears, Christopher
AU - Betts, John M
AU - Reynolds, Hayley M
AU - Tack, Guido
AU - Leo, Kevin
AU - Williams, Scott Garrick
AU - Ebert, Martin A
PY - 2016
Y1 - 2016
N2 - Treatment plans for ten patients, initially treated with a conventional approach to low doserate brachytherapy (LDR, 145 Gy to entire prostate), were compared with plans for the same patients created with an inverseoptimisation planning process utilising a biologically based objective. The 'biological optimisation' considered a nonuniform distribution of tumour cell density through the prostate based on known and expected locations of the tumour. Using dose planningobjectives derived from our previous biologicalmodel validation study, the volume of the urethra receiving 125% of the conventional prescription (145 Gy) was reduced from a median value of 64% to less than 8% whilst maintaining high values of TCP. On average, the number of planned seeds was reduced from 85 to less than 75. The robustness of plans to random seed displacements needs to be carefully considered when using contemporary seed placement techniques. We conclude that an inverse planning approach to LDR treatments, based on a biological objective, has the potential to maintain high rates of tumour control whilst minimising dose to healthy tissue. In future, the radiobiological model will be informed using multiparametric MRI to provide a personalised medicine approach.
AB - Treatment plans for ten patients, initially treated with a conventional approach to low doserate brachytherapy (LDR, 145 Gy to entire prostate), were compared with plans for the same patients created with an inverseoptimisation planning process utilising a biologically based objective. The 'biological optimisation' considered a nonuniform distribution of tumour cell density through the prostate based on known and expected locations of the tumour. Using dose planningobjectives derived from our previous biologicalmodel validation study, the volume of the urethra receiving 125% of the conventional prescription (145 Gy) was reduced from a median value of 64% to less than 8% whilst maintaining high values of TCP. On average, the number of planned seeds was reduced from 85 to less than 75. The robustness of plans to random seed displacements needs to be carefully considered when using contemporary seed placement techniques. We conclude that an inverse planning approach to LDR treatments, based on a biological objective, has the potential to maintain high rates of tumour control whilst minimising dose to healthy tissue. In future, the radiobiological model will be informed using multiparametric MRI to provide a personalised medicine approach.
UR - http://iopscience.iop.org/article/10.1088/0031-9155/61/1/430/pdf
U2 - 10.1088/0031-9155/61/1/430
DO - 10.1088/0031-9155/61/1/430
M3 - Article
VL - 61
SP - 430
EP - 444
JO - Physics in Medicine and Biology
JF - Physics in Medicine and Biology
SN - 0031-9155
IS - 1
ER -