A putative Plasmodium falciparum exported serine/threonine protein kinase

Jürgen F J J Kun; Alan R. Hibbs; Allan Saul; Damian J. McColl; Ross L. Coppel; Robin F. Anders

doi:10.1016/S0166-6851(96)02805-8

A putative Plasmodium falciparum exported serine/threonine protein kinase

Jürgen F J J Kun, Alan R. Hibbs, Allan Saul, Damian J. McColl, Ross L. Coppel, Robin F. Anders

Microbiology

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Abstract

An 8 kb gene coding for a putative serine/threonine protein kinase from Plasmodium falciparum has been cloned and sequenced. It is arranged in two exons: exon I is 2 kb and exon II is 5.6 kb. The gene codes for a large protein of 2510 amino acids. Antibodies raised against a fusion protein were used to localize the putative kinase. By immunofluorescence microscopy, it was found in the cytoplasm of infected red cells. By immunoelectron microscopy it was associated with membranous structures in the red cell and with the red cell membrane, particularly at parasite-induced knobs. This is the first putative protein kinase of P. falciparum to be exported from the parasite into its host cell.

Original language	English
Pages (from-to)	41-51
Number of pages	11
Journal	Molecular and Biochemical Parasitology
Volume	85
Issue number	1
DOIs	https://doi.org/10.1016/S0166-6851(96)02805-8
Publication status	Published - 1 Mar 1997

Keywords

cytoskeleton
falciparum exported serine/threonine kinase
Plasmodium falciparum
ring-infected erythrocyte surface antigen
serine/threonine protein kinase

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AU - Coppel, Ross L.

AU - Anders, Robin F.

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A putative Plasmodium falciparum exported serine/threonine protein kinase

Abstract

Keywords

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