Abstract
Cryoprecipitate is a concentrate of high-molecular-weight plasma proteins that precipitate when frozen
plasma is slowly thawed at 1a??6A?C. The concentrate contains factor VIII (antihemophilic factor), von
Willebrand factor (vWF), fibrinogen, factor XIII, fibronectin, and small amounts of other plasma proteins. Clinical-grade preparations of cryoprecipitate are mainly used to treat fibrinogen deficiency caused
by acute bleeding or functional abnormalities of the fibrinogen protein. In the past, cryoprecipitate was
used to treat von Willebrand disease and hemophilia A (factor VIII deficiency), but the availability of
more highly purified coagulation factor concentrates or recombinant protein preparations has superseded
the use of cryoprecipitate for these coagulopathies. Cryodepleted plasma (a??cryosupernatanta??) is the
plasma supernatant that remains following removal of the cryoprecipitate from frozen-thawed plasma.
It contains all the other plasma proteins and clotting factors present in plasma that remain soluble during
cold-temperature thawing of the plasma.
Original language | English |
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Title of host publication | Serum/Plasma Proteomics: Methods and Protocols |
Editors | Richard J Simpson, David W Greening |
Place of Publication | UK |
Publisher | Humana Press |
Pages | 259 - 265 |
Number of pages | 7 |
Volume | 728 |
ISBN (Print) | 9781617790676 |
DOIs | |
Publication status | Published - 2011 |