Abstract
Ty virus-like particles consist of a single protein species that can be produced in yeast. Recombinant Ty-VLPs carrying a string of up to 15 defined cytotoxic T lymphocyte (CTL) epitopes from Plasmodium species prime protective CTL responses in mice following a single administration without adjuvant. Effective processing of epitopes from the string was demonstrated in vitro and in vivo and was not affected by flanking sequences.
Original language | English |
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Pages (from-to) | 1280-1284 |
Number of pages | 5 |
Journal | Nature Biotechnology |
Volume | 15 |
Issue number | 12 |
DOIs | |
Publication status | Published - 1997 |
Externally published | Yes |
Keywords
- Antigen presentation
- Vaccine design