A protein particle vaccine containing multiple malaria epitopes

Sarah C. Gilbert, Magdalena Plebanski, Stephen J. Harris, Catherine E M Allsopp, Rebecca Thomas, Guy T. Layton, Adrian V S Hill

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133 Citations (Scopus)

Abstract

Ty virus-like particles consist of a single protein species that can be produced in yeast. Recombinant Ty-VLPs carrying a string of up to 15 defined cytotoxic T lymphocyte (CTL) epitopes from Plasmodium species prime protective CTL responses in mice following a single administration without adjuvant. Effective processing of epitopes from the string was demonstrated in vitro and in vivo and was not affected by flanking sequences.

Original languageEnglish
Pages (from-to)1280-1284
Number of pages5
JournalNature Biotechnology
Volume15
Issue number12
DOIs
Publication statusPublished - 1997
Externally publishedYes

Keywords

  • Antigen presentation
  • Vaccine design

Cite this

Gilbert, S. C., Plebanski, M., Harris, S. J., Allsopp, C. E. M., Thomas, R., Layton, G. T., & Hill, A. V. S. (1997). A protein particle vaccine containing multiple malaria epitopes. Nature Biotechnology, 15(12), 1280-1284. https://doi.org/10.1038/nbt1197-1280