A prospective study of hormonal treatment and anxiety disorders in community-dwelling elderly women (The Esprit Study)

Jacqueline Scali, Joanne Ryan, Isabelle Carrière, Karen Anne Ritchie, Marie-Laure Ancelin

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5 Citations (Scopus)


Background: The impact of hormone therapy use on late-life anxiety disorder in elderly women has not been evaluated. Methods: Anxiety disorders were evaluated in 838 community-dwelling postmenopausal women aged 65 years and over, randomly recruited from electoral rolls. Anxiety disorders were assessed using a standardized psychiatric examination based on DSM-IV criteria, at baseline and as part of the 2- and 4-year follow-up. Results: Multivariate logistic regression analyses adjusted for socio-demographic variables, measures of physical health and cognitive impairment, as well as current depressive symptomatology indicated no significant association between hormone therapy and anxiety disorders at baseline or after the 4-year follow-up period, regardless of type of treatment. Compared to women who have never taken hormonal therapy, no significant difference was observed for women taking continuously hormone therapy over the follow-up or those who stopped their treatment. Conclusions: The use of hormone therapy was not associated with improved anxiety symptomatology in elderly postmenopausal women.

Original languageEnglish
Pages (from-to)274-279
Number of pages6
JournalJournal of Affective Disorders
Issue number1-2
Publication statusPublished - May 2009
Externally publishedYes


  • Anxiety
  • Estradiol
  • Postmenopausal
  • Progestogen
  • Transdermal

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