A Prospective Analysis of Olfactory Impairment Recovery After Severe Traumatic Brain Injury

Melanie Drummond, Jacinta Douglas, John Olver

Research output: Contribution to journalArticleResearchpeer-review

Abstract

OBJECTIVE:: To investigate the natural progression of olfactory impairment (OI) in individuals with traumatic brain injury (TBI) at 6 months postinjury. PARTICIPANTS:: Forty-seven adults (mean age = 43.1 years, SD = 18.2), with predominantly severe TBI (mean posttraumatic amnesia [PTA] duration = 25.5 days, SD = 22.8). DESIGN:: Consecutive admission longitudinal study. MAIN MEASURES:: Participants were evaluated using the University of Pennsylvania Smell Identification Test (UPSIT) at resolution of PTA and at 6 months post–initial injury. Each participant was also interviewed to explore his or her experience of having an OI. Standard multiple regression was used to assess the ability of age, PTA duration, presence of facial fractures, and initial UPSIT score to predict olfactory performance at 6 months. RESULTS:: Thirty-five participants (74%) continued to demonstrate OI at 6 months. Thirty-two participants (68%) showed some improvement, but only 12 of these individuals achieved scores within the normal range. The remaining 15 participants either produced a poorer performance (23%) or demonstrated no change (9%). Initial UPSIT score uniquely accounted for 73.5% of the variance in UPSIT performance at 6 months. CONCLUSIONS:: Olfactory impairment persists in a substantial proportion of adults who experience it post-TBI and has the potential to impact a broad spectrum of everyday activities.

Original languageEnglish
Pages (from-to)53-61
Number of pages9
JournalJournal of Head Trauma Rehabilitation
Volume33
Issue number1
DOIs
Publication statusPublished - Jan 2018
Externally publishedYes

Cite this

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title = "A Prospective Analysis of Olfactory Impairment Recovery After Severe Traumatic Brain Injury",
abstract = "OBJECTIVE:: To investigate the natural progression of olfactory impairment (OI) in individuals with traumatic brain injury (TBI) at 6 months postinjury. PARTICIPANTS:: Forty-seven adults (mean age = 43.1 years, SD = 18.2), with predominantly severe TBI (mean posttraumatic amnesia [PTA] duration = 25.5 days, SD = 22.8). DESIGN:: Consecutive admission longitudinal study. MAIN MEASURES:: Participants were evaluated using the University of Pennsylvania Smell Identification Test (UPSIT) at resolution of PTA and at 6 months post–initial injury. Each participant was also interviewed to explore his or her experience of having an OI. Standard multiple regression was used to assess the ability of age, PTA duration, presence of facial fractures, and initial UPSIT score to predict olfactory performance at 6 months. RESULTS:: Thirty-five participants (74{\%}) continued to demonstrate OI at 6 months. Thirty-two participants (68{\%}) showed some improvement, but only 12 of these individuals achieved scores within the normal range. The remaining 15 participants either produced a poorer performance (23{\%}) or demonstrated no change (9{\%}). Initial UPSIT score uniquely accounted for 73.5{\%} of the variance in UPSIT performance at 6 months. CONCLUSIONS:: Olfactory impairment persists in a substantial proportion of adults who experience it post-TBI and has the potential to impact a broad spectrum of everyday activities.",
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A Prospective Analysis of Olfactory Impairment Recovery After Severe Traumatic Brain Injury. / Drummond, Melanie; Douglas, Jacinta; Olver, John.

In: Journal of Head Trauma Rehabilitation, Vol. 33, No. 1, 01.2018, p. 53-61.

Research output: Contribution to journalArticleResearchpeer-review

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AB - OBJECTIVE:: To investigate the natural progression of olfactory impairment (OI) in individuals with traumatic brain injury (TBI) at 6 months postinjury. PARTICIPANTS:: Forty-seven adults (mean age = 43.1 years, SD = 18.2), with predominantly severe TBI (mean posttraumatic amnesia [PTA] duration = 25.5 days, SD = 22.8). DESIGN:: Consecutive admission longitudinal study. MAIN MEASURES:: Participants were evaluated using the University of Pennsylvania Smell Identification Test (UPSIT) at resolution of PTA and at 6 months post–initial injury. Each participant was also interviewed to explore his or her experience of having an OI. Standard multiple regression was used to assess the ability of age, PTA duration, presence of facial fractures, and initial UPSIT score to predict olfactory performance at 6 months. RESULTS:: Thirty-five participants (74%) continued to demonstrate OI at 6 months. Thirty-two participants (68%) showed some improvement, but only 12 of these individuals achieved scores within the normal range. The remaining 15 participants either produced a poorer performance (23%) or demonstrated no change (9%). Initial UPSIT score uniquely accounted for 73.5% of the variance in UPSIT performance at 6 months. CONCLUSIONS:: Olfactory impairment persists in a substantial proportion of adults who experience it post-TBI and has the potential to impact a broad spectrum of everyday activities.

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