A preliminary screening of potentially antimalarial plants against Plasmodium falciparum in vitro

Loke Tim Khaw; Nontawat Leerach; Nan-Jiun Yap; Narong Jaturas; Tooba Mahboob; T C Tan; Julieta Z Dungca; Zenaida D LosBanos; Sutthirat Sitthisak; Chow Sek Chuen; Yvonne Ai Lian Lim; Nongyao Sawangjaroen; Christophe Wiart; Veeranoot Nissapatorn

A preliminary screening of potentially antimalarial plants against Plasmodium falciparum in vitro

Loke Tim Khaw, Nontawat Leerach, Nan-Jiun Yap, Narong Jaturas, Tooba Mahboob, T C Tan, Julieta Z Dungca, Zenaida D LosBanos, Sutthirat Sitthisak, Chow Sek Chuen, Yvonne Ai Lian Lim, Nongyao Sawangjaroen, Christophe Wiart, Veeranoot Nissapatorn

Research output: Contribution to journal › Article › Research › peer-review

1 Citation (Scopus)

Abstract

Plasmodium is a blood protozoan parasite that is responsible for malaria. To date, Plasmodium falciparum has shown multi-drug resistance, particularly in Thailand, Myanmar and Malaysia. The aim of the study is to screen the plant extracts that can effectively inhibit P. falciparum 3D7, a common lab strain malaria parasite. Nine plants were collected and processed through maceration using hexane, chloroform and ethanol, resulting in 24 crude plant extracts. Of these, extracts from Artabotrys crassifolius, Pericampylus glacus and Leuconotis eugeniifolia showed promising antiplasmodial activities at IC50 of 15.32 to 39.75 ?g/mL in a modified schizont maturation assay. Further studies are warranted to explore its efficacies and lead compounds of these three plant extracts for the development of antiplasmodial drugs.

Original language	English
Pages (from-to)	676 - 683
Number of pages	8
Journal	Tropical Biomedicine
Volume	32
Issue number	4
Publication status	Published - 2015

Cite this

Khaw, Loke Tim ; Leerach, Nontawat ; Yap, Nan-Jiun ; Jaturas, Narong ; Mahboob, Tooba ; Tan, T C ; Dungca, Julieta Z ; LosBanos, Zenaida D ; Sitthisak, Sutthirat ; Chuen, Chow Sek ; Lim, Yvonne Ai Lian ; Sawangjaroen, Nongyao ; Wiart, Christophe ; Nissapatorn, Veeranoot. / A preliminary screening of potentially antimalarial plants against Plasmodium falciparum in vitro. In: Tropical Biomedicine. 2015 ; Vol. 32, No. 4. pp. 676 - 683.

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abstract = "Plasmodium is a blood protozoan parasite that is responsible for malaria. To date, Plasmodium falciparum has shown multi-drug resistance, particularly in Thailand, Myanmar and Malaysia. The aim of the study is to screen the plant extracts that can effectively inhibit P. falciparum 3D7, a common lab strain malaria parasite. Nine plants were collected and processed through maceration using hexane, chloroform and ethanol, resulting in 24 crude plant extracts. Of these, extracts from Artabotrys crassifolius, Pericampylus glacus and Leuconotis eugeniifolia showed promising antiplasmodial activities at IC50 of 15.32 to 39.75 ?g/mL in a modified schizont maturation assay. Further studies are warranted to explore its efficacies and lead compounds of these three plant extracts for the development of antiplasmodial drugs.",

author = "Khaw, {Loke Tim} and Nontawat Leerach and Nan-Jiun Yap and Narong Jaturas and Tooba Mahboob and Tan, {T C} and Dungca, {Julieta Z} and LosBanos, {Zenaida D} and Sutthirat Sitthisak and Chuen, {Chow Sek} and Lim, {Yvonne Ai Lian} and Nongyao Sawangjaroen and Christophe Wiart and Veeranoot Nissapatorn",

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volume = "32",

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journal = "Tropical Biomedicine",

issn = "0127-5720",

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A preliminary screening of potentially antimalarial plants against Plasmodium falciparum in vitro. / Khaw, Loke Tim; Leerach, Nontawat; Yap, Nan-Jiun; Jaturas, Narong; Mahboob, Tooba; Tan, T C; Dungca, Julieta Z; LosBanos, Zenaida D; Sitthisak, Sutthirat; Chuen, Chow Sek; Lim, Yvonne Ai Lian; Sawangjaroen, Nongyao; Wiart, Christophe; Nissapatorn, Veeranoot.

In: Tropical Biomedicine, Vol. 32, No. 4, 2015, p. 676 - 683.

Research output: Contribution to journal › Article › Research › peer-review

TY - JOUR

T1 - A preliminary screening of potentially antimalarial plants against Plasmodium falciparum in vitro

AU - Khaw, Loke Tim

AU - Leerach, Nontawat

AU - Yap, Nan-Jiun

AU - Jaturas, Narong

AU - Mahboob, Tooba

AU - Tan, T C

AU - Dungca, Julieta Z

AU - LosBanos, Zenaida D

AU - Sitthisak, Sutthirat

AU - Chuen, Chow Sek

AU - Lim, Yvonne Ai Lian

AU - Sawangjaroen, Nongyao

AU - Wiart, Christophe

AU - Nissapatorn, Veeranoot

PY - 2015

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AB - Plasmodium is a blood protozoan parasite that is responsible for malaria. To date, Plasmodium falciparum has shown multi-drug resistance, particularly in Thailand, Myanmar and Malaysia. The aim of the study is to screen the plant extracts that can effectively inhibit P. falciparum 3D7, a common lab strain malaria parasite. Nine plants were collected and processed through maceration using hexane, chloroform and ethanol, resulting in 24 crude plant extracts. Of these, extracts from Artabotrys crassifolius, Pericampylus glacus and Leuconotis eugeniifolia showed promising antiplasmodial activities at IC50 of 15.32 to 39.75 ?g/mL in a modified schizont maturation assay. Further studies are warranted to explore its efficacies and lead compounds of these three plant extracts for the development of antiplasmodial drugs.

M3 - Article

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JO - Tropical Biomedicine

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