TY - JOUR
T1 - A potential new target for autoinflammatory bone disease
AU - Hartland, Elizabeth L.
PY - 2020/3/13
Y1 - 2020/3/13
N2 - Chronic recurrent multifocal osteomyelitis (CRMO) is an autoinflammatory bone disease mediated by the inflammatory cytokine, IL-1β. Although IL-1β is known as the key driver of bone lesions in CRMO, the signaling events leading to pathogenic levels of the cytokine are not fully understood. Using a genetic mouse model of CRMO, Dasari et al. find a role for the nonreceptor spleen tyrosine kinase (SYK) in upstream signaling leading to IL-1β up-regulation. Their findings suggest that SYK may constitute a new therapeutic target for CRMO.
AB - Chronic recurrent multifocal osteomyelitis (CRMO) is an autoinflammatory bone disease mediated by the inflammatory cytokine, IL-1β. Although IL-1β is known as the key driver of bone lesions in CRMO, the signaling events leading to pathogenic levels of the cytokine are not fully understood. Using a genetic mouse model of CRMO, Dasari et al. find a role for the nonreceptor spleen tyrosine kinase (SYK) in upstream signaling leading to IL-1β up-regulation. Their findings suggest that SYK may constitute a new therapeutic target for CRMO.
UR - http://www.scopus.com/inward/record.url?scp=85081964973&partnerID=8YFLogxK
U2 - 10.1074/jbc.H120.012867
DO - 10.1074/jbc.H120.012867
M3 - Editorial
C2 - 32169854
AN - SCOPUS:85081964973
VL - 295
SP - 3401
EP - 3402
JO - The Journal of Biological Chemistry
JF - The Journal of Biological Chemistry
SN - 1083-351X
IS - 11
ER -