A potent alpha-glucosidase inhibitor from Myristica cinnamomea King

Yasodha Sivasothy, Kong Yong Loo, Kok Hoong Leong, Marc Litaudon, Khalijah Awang, Khalijah Awang

Research output: Contribution to journalArticleResearchpeer-review

39 Citations (Scopus)


A dimeric acylphenol and a potent α-glucosidase inhibitor, giganteone D (IC50 5.05 μM), was isolated and characterized from the bark of Myristica cinnamomea King. The bark also yielded an acylphenol with an unprecedented skeleton for which the name cinnamomeone A (IC50 358.80 μM) was proposed. Their structures were established by means of NMR and MS spectrometric analyses. The Lineweaver-Burk plot of giganteone D indicated that it was a mixed-type inhibitor. This is the first report on the α-glucosidase inhibiting potential of acylphenols.

Original languageEnglish
Pages (from-to)265-269
Number of pages5
Publication statusPublished - Feb 2016
Externally publishedYes


  • Acylphenol
  • Cinnamomeone A
  • Dimeric acylphenol
  • Giganteone D
  • Myristica cinnamomea King
  • Myristicaceae
  • α-Glucosidase inhibitor

Cite this