TY - JOUR
T1 - A polymorphism in IL4 may associate with sensory neuropathy in African HIV patients
AU - Wadley, A
AU - Kamerman, P
AU - Chew, Constance S N
AU - Lombard, Zane
AU - Cherry, Catherine
AU - Price, Patricia
PY - 2013
Y1 - 2013
N2 - Introduction Animal and in vitro models of HIV-associated sensory neuropathy suggest an inflammatory etiology. Previous genetic association studies of HIV-SN have been in small Caucasian or Asian cohorts. We assessed cytokine single nucleotide polymorphisms (SNPs) in a Black Southern African cohort. Method 342 black HIV-positive Southern Africans were recruited. 190 individuals had HIV-associated sensory neuropathy and 152 did not. DNA samples from all participants were genotyped for cytokine SNPs identified in studies of HIV disease and/or neuropathy. Results IL4-590*T associated with an increased prevalence of HIV-SN including following correction for age, height and CD4 T-cell count. No other cytokine SNPs assessed displayed an association. Discussion We identified a novel association between IL4-590*T and HIV-SN in African HIV-positive patients which warrants further investigation. ? 2013 Elsevier Ltd.
AB - Introduction Animal and in vitro models of HIV-associated sensory neuropathy suggest an inflammatory etiology. Previous genetic association studies of HIV-SN have been in small Caucasian or Asian cohorts. We assessed cytokine single nucleotide polymorphisms (SNPs) in a Black Southern African cohort. Method 342 black HIV-positive Southern Africans were recruited. 190 individuals had HIV-associated sensory neuropathy and 152 did not. DNA samples from all participants were genotyped for cytokine SNPs identified in studies of HIV disease and/or neuropathy. Results IL4-590*T associated with an increased prevalence of HIV-SN including following correction for age, height and CD4 T-cell count. No other cytokine SNPs assessed displayed an association. Discussion We identified a novel association between IL4-590*T and HIV-SN in African HIV-positive patients which warrants further investigation. ? 2013 Elsevier Ltd.
UR - http://www.sciencedirect.com/science/article/pii/S0161589013000400
U2 - 10.1016/j.molimm.2013.02.002
DO - 10.1016/j.molimm.2013.02.002
M3 - Article
SN - 0161-5890
VL - 55
SP - 197
EP - 199
JO - Molecular Immunology
JF - Molecular Immunology
IS - 3-4
ER -