A polymorphism in IL4 may associate with sensory neuropathy in African HIV patients

A Wadley, P Kamerman, Constance S N Chew, Zane Lombard, Catherine Cherry, Patricia Price

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9 Citations (Scopus)

Abstract

Introduction Animal and in vitro models of HIV-associated sensory neuropathy suggest an inflammatory etiology. Previous genetic association studies of HIV-SN have been in small Caucasian or Asian cohorts. We assessed cytokine single nucleotide polymorphisms (SNPs) in a Black Southern African cohort. Method 342 black HIV-positive Southern Africans were recruited. 190 individuals had HIV-associated sensory neuropathy and 152 did not. DNA samples from all participants were genotyped for cytokine SNPs identified in studies of HIV disease and/or neuropathy. Results IL4-590*T associated with an increased prevalence of HIV-SN including following correction for age, height and CD4 T-cell count. No other cytokine SNPs assessed displayed an association. Discussion We identified a novel association between IL4-590*T and HIV-SN in African HIV-positive patients which warrants further investigation. ? 2013 Elsevier Ltd.
Original languageEnglish
Pages (from-to)197 - 199
Number of pages3
JournalMolecular Immunology
Volume55
Issue number3-4
DOIs
Publication statusPublished - 2013

Cite this

Wadley, A ; Kamerman, P ; Chew, Constance S N ; Lombard, Zane ; Cherry, Catherine ; Price, Patricia. / A polymorphism in IL4 may associate with sensory neuropathy in African HIV patients. In: Molecular Immunology. 2013 ; Vol. 55, No. 3-4. pp. 197 - 199.
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abstract = "Introduction Animal and in vitro models of HIV-associated sensory neuropathy suggest an inflammatory etiology. Previous genetic association studies of HIV-SN have been in small Caucasian or Asian cohorts. We assessed cytokine single nucleotide polymorphisms (SNPs) in a Black Southern African cohort. Method 342 black HIV-positive Southern Africans were recruited. 190 individuals had HIV-associated sensory neuropathy and 152 did not. DNA samples from all participants were genotyped for cytokine SNPs identified in studies of HIV disease and/or neuropathy. Results IL4-590*T associated with an increased prevalence of HIV-SN including following correction for age, height and CD4 T-cell count. No other cytokine SNPs assessed displayed an association. Discussion We identified a novel association between IL4-590*T and HIV-SN in African HIV-positive patients which warrants further investigation. ? 2013 Elsevier Ltd.",
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A polymorphism in IL4 may associate with sensory neuropathy in African HIV patients. / Wadley, A; Kamerman, P; Chew, Constance S N; Lombard, Zane; Cherry, Catherine; Price, Patricia.

In: Molecular Immunology, Vol. 55, No. 3-4, 2013, p. 197 - 199.

Research output: Contribution to journalArticleResearchpeer-review

TY - JOUR

T1 - A polymorphism in IL4 may associate with sensory neuropathy in African HIV patients

AU - Wadley, A

AU - Kamerman, P

AU - Chew, Constance S N

AU - Lombard, Zane

AU - Cherry, Catherine

AU - Price, Patricia

PY - 2013

Y1 - 2013

N2 - Introduction Animal and in vitro models of HIV-associated sensory neuropathy suggest an inflammatory etiology. Previous genetic association studies of HIV-SN have been in small Caucasian or Asian cohorts. We assessed cytokine single nucleotide polymorphisms (SNPs) in a Black Southern African cohort. Method 342 black HIV-positive Southern Africans were recruited. 190 individuals had HIV-associated sensory neuropathy and 152 did not. DNA samples from all participants were genotyped for cytokine SNPs identified in studies of HIV disease and/or neuropathy. Results IL4-590*T associated with an increased prevalence of HIV-SN including following correction for age, height and CD4 T-cell count. No other cytokine SNPs assessed displayed an association. Discussion We identified a novel association between IL4-590*T and HIV-SN in African HIV-positive patients which warrants further investigation. ? 2013 Elsevier Ltd.

AB - Introduction Animal and in vitro models of HIV-associated sensory neuropathy suggest an inflammatory etiology. Previous genetic association studies of HIV-SN have been in small Caucasian or Asian cohorts. We assessed cytokine single nucleotide polymorphisms (SNPs) in a Black Southern African cohort. Method 342 black HIV-positive Southern Africans were recruited. 190 individuals had HIV-associated sensory neuropathy and 152 did not. DNA samples from all participants were genotyped for cytokine SNPs identified in studies of HIV disease and/or neuropathy. Results IL4-590*T associated with an increased prevalence of HIV-SN including following correction for age, height and CD4 T-cell count. No other cytokine SNPs assessed displayed an association. Discussion We identified a novel association between IL4-590*T and HIV-SN in African HIV-positive patients which warrants further investigation. ? 2013 Elsevier Ltd.

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DO - 10.1016/j.molimm.2013.02.002

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VL - 55

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JO - Molecular Immunology

JF - Molecular Immunology

SN - 0161-5890

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