A Pioneering Career in Catalysis: Manfred T. Reetz

Carlos G. Acevedo-Rocha, Frank Hollmann, Joaquin Sanchis, Zhoutong Sun

Research output: Contribution to journalArticleOtherpeer-review

Abstract

In this invited Account, we highlight the enormous scientific breadth of our mentor Professor Manfred T. Reetz. It stretches from the development of organometallic reagents and transition metal catalysts to the adventurous idea of directed evolution of chemo-, stereo-, and regioselective enzymes, which he considered to be most important. We hope to show that Reetz did not consider these research areas to be totally unrelated realms, and attempt to reveal his transdisciplinary way of thinking about methodology development. Since biocatalysis has become crucial for chemical synthesis, we mainly focus on Reetz's contributions in this area. Some personal reflections from some of his former co-workers are also included, which reveal the stimulating atmosphere in the Reetz group in terms of science, career advice, and the importance of ethical considerations.

Original languageEnglish
Pages (from-to)15123-15139
Number of pages17
JournalACS Catalysis
Volume10
Issue number24
DOIs
Publication statusPublished - 8 Dec 2020

Keywords

  • biocatalysis
  • directed evolution
  • protein engineering
  • regioselectivity
  • saturation mutagenesis
  • stereoselectivity

Cite this