A pharmacological approach to first aid treatment for snakebite

Megan E. Saul; Paul A. Thomas; Peter J. Dosen; Geoffrey K. Isbister; Margaret A O'Leary; Ian M Whyte; Sally A. McFadden; Dirk F. Van Helden

doi:10.1038/nm.2382

A pharmacological approach to first aid treatment for snakebite

Megan E. Saul, Paul A. Thomas, Peter J. Dosen, Geoffrey K. Isbister, Margaret A O'Leary, Ian M Whyte, Sally A. McFadden, Dirk F. Van Helden

Research output: Contribution to journal › Article › Research › peer-review

35 Citations (Scopus)

Abstract

Snake venom toxins first transit the lymphatic system before entering the bloodstream. Ointment containing a nitric oxide donor, which impedes the intrinsic lymphatic pump, prolonged lymph transit time in rats and humans and also increased rat survival time after injection of venom. This pharmacological approach should give snakebite victims more time to obtain medical care and antivenom treatment.

Original language	English
Pages (from-to)	809-811
Number of pages	3
Journal	Nature Medicine
Volume	17
Issue number	7
DOIs	https://doi.org/10.1038/nm.2382
Publication status	Published - Jul 2011
Externally published	Yes

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10.1038/nm.2382

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abstract = "Snake venom toxins first transit the lymphatic system before entering the bloodstream. Ointment containing a nitric oxide donor, which impedes the intrinsic lymphatic pump, prolonged lymph transit time in rats and humans and also increased rat survival time after injection of venom. This pharmacological approach should give snakebite victims more time to obtain medical care and antivenom treatment.",

author = "Saul, {Megan E.} and Thomas, {Paul A.} and Dosen, {Peter J.} and Isbister, {Geoffrey K.} and O'Leary, {Margaret A} and Whyte, {Ian M} and McFadden, {Sally A.} and {Van Helden}, {Dirk F.}",

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AU - Whyte, Ian M

AU - McFadden, Sally A.

AU - Van Helden, Dirk F.

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AB - Snake venom toxins first transit the lymphatic system before entering the bloodstream. Ointment containing a nitric oxide donor, which impedes the intrinsic lymphatic pump, prolonged lymph transit time in rats and humans and also increased rat survival time after injection of venom. This pharmacological approach should give snakebite victims more time to obtain medical care and antivenom treatment.

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A pharmacological approach to first aid treatment for snakebite

Abstract

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