A pH-responsive asymmetric lipid vesicle as drug carrier

Xunan Zhang; Wei Zong; Ying Hu; Nan Luo; Wenlong Cheng; Xiaojun Han

doi:10.1080/02652048.2016.1242668

A pH-responsive asymmetric lipid vesicle as drug carrier

Xunan Zhang
, Wei Zong
, Ying Hu
, Nan Luo
, Wenlong Cheng
, Xiaojun Han

Chemical & Biological Engineering

Research output: Contribution to journal › Article › Research › peer-review

18 Citations (Scopus)

Abstract

In order to increase the loading efficiency of drug carriers, here we demonstrated a microfluidic method to fabricate an asymmetric vesicle, which contains trichloro(1H,1H,2H,2H-perfluoroocty-l)silane (TPS) inner leaflet and lipid outer leaflet. The asymmetric vesicle was characterised by fluorescence microscopy and Fourier transform infra-red spectrum. In vitro cytotoxicity of the vesicles carrying 5-fluorouacil (5-FU) has also been studied.

Original language	English
Pages (from-to)	663-668
Number of pages	6
Journal	Journal of Microencapsulation
Volume	33
Issue number	7
DOIs	https://doi.org/10.1080/02652048.2016.1242668
Publication status	Published - 2 Oct 2016

Keywords

asymmetric vesicles
drug delivery
Lipid
microfluidics
self-assembly

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10.1080/02652048.2016.1242668

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AU - Zhang, Xunan

AU - Zong, Wei

AU - Hu, Ying

AU - Luo, Nan

AU - Cheng, Wenlong

AU - Han, Xiaojun

PY - 2016/10/2

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AB - In order to increase the loading efficiency of drug carriers, here we demonstrated a microfluidic method to fabricate an asymmetric vesicle, which contains trichloro(1H,1H,2H,2H-perfluoroocty-l)silane (TPS) inner leaflet and lipid outer leaflet. The asymmetric vesicle was characterised by fluorescence microscopy and Fourier transform infra-red spectrum. In vitro cytotoxicity of the vesicles carrying 5-fluorouacil (5-FU) has also been studied.

KW - asymmetric vesicles

KW - drug delivery

KW - Lipid

KW - microfluidics

KW - self-assembly

UR - https://www.scopus.com/pages/publications/84992073654

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JO - Journal of Microencapsulation

JF - Journal of Microencapsulation

IS - 7

ER -

A pH-responsive asymmetric lipid vesicle as drug carrier

Abstract

Keywords

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