A pH-responsive asymmetric lipid vesicle as drug carrier

Xunan Zhang, Wei Zong, Ying Hu, Nan Luo, Wenlong Cheng, Xiaojun Han

Research output: Contribution to journalArticleResearchpeer-review

Abstract

In order to increase the loading efficiency of drug carriers, here we demonstrated a microfluidic method to fabricate an asymmetric vesicle, which contains trichloro(1H,1H,2H,2H-perfluoroocty-l)silane (TPS) inner leaflet and lipid outer leaflet. The asymmetric vesicle was characterised by fluorescence microscopy and Fourier transform infra-red spectrum. In vitro cytotoxicity of the vesicles carrying 5-fluorouacil (5-FU) has also been studied.

Original languageEnglish
Pages (from-to)663-668
Number of pages6
JournalJournal of Microencapsulation
Volume33
Issue number7
DOIs
Publication statusPublished - 2 Oct 2016

Keywords

  • asymmetric vesicles
  • drug delivery
  • Lipid
  • microfluidics
  • self-assembly

Cite this

Zhang, Xunan ; Zong, Wei ; Hu, Ying ; Luo, Nan ; Cheng, Wenlong ; Han, Xiaojun. / A pH-responsive asymmetric lipid vesicle as drug carrier. In: Journal of Microencapsulation. 2016 ; Vol. 33, No. 7. pp. 663-668.
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A pH-responsive asymmetric lipid vesicle as drug carrier. / Zhang, Xunan; Zong, Wei; Hu, Ying; Luo, Nan; Cheng, Wenlong; Han, Xiaojun.

In: Journal of Microencapsulation, Vol. 33, No. 7, 02.10.2016, p. 663-668.

Research output: Contribution to journalArticleResearchpeer-review

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AU - Zhang, Xunan

AU - Zong, Wei

AU - Hu, Ying

AU - Luo, Nan

AU - Cheng, Wenlong

AU - Han, Xiaojun

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KW - drug delivery

KW - Lipid

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KW - self-assembly

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