A pH-responsive asymmetric lipid vesicle as drug carrier

Xunan Zhang, Wei Zong, Ying Hu, Nan Luo, Wenlong Cheng, Xiaojun Han

Research output: Contribution to journalArticleResearchpeer-review

10 Citations (Scopus)

Abstract

In order to increase the loading efficiency of drug carriers, here we demonstrated a microfluidic method to fabricate an asymmetric vesicle, which contains trichloro(1H,1H,2H,2H-perfluoroocty-l)silane (TPS) inner leaflet and lipid outer leaflet. The asymmetric vesicle was characterised by fluorescence microscopy and Fourier transform infra-red spectrum. In vitro cytotoxicity of the vesicles carrying 5-fluorouacil (5-FU) has also been studied.

Original languageEnglish
Pages (from-to)663-668
Number of pages6
JournalJournal of Microencapsulation
Volume33
Issue number7
DOIs
Publication statusPublished - 2 Oct 2016

Keywords

  • asymmetric vesicles
  • drug delivery
  • Lipid
  • microfluidics
  • self-assembly

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