Abstract
In order to increase the loading efficiency of drug carriers, here we demonstrated a microfluidic method to fabricate an asymmetric vesicle, which contains trichloro(1H,1H,2H,2H-perfluoroocty-l)silane (TPS) inner leaflet and lipid outer leaflet. The asymmetric vesicle was characterised by fluorescence microscopy and Fourier transform infra-red spectrum. In vitro cytotoxicity of the vesicles carrying 5-fluorouacil (5-FU) has also been studied.
| Original language | English |
|---|---|
| Pages (from-to) | 663-668 |
| Number of pages | 6 |
| Journal | Journal of Microencapsulation |
| Volume | 33 |
| Issue number | 7 |
| DOIs | |
| Publication status | Published - 2 Oct 2016 |
Keywords
- asymmetric vesicles
- drug delivery
- Lipid
- microfluidics
- self-assembly
Cite this
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A pH-responsive asymmetric lipid vesicle as drug carrier. / Zhang, Xunan; Zong, Wei; Hu, Ying; Luo, Nan; Cheng, Wenlong; Han, Xiaojun.
In: Journal of Microencapsulation, Vol. 33, No. 7, 02.10.2016, p. 663-668.Research output: Contribution to journal › Article › Research › peer-review
TY - JOUR
T1 - A pH-responsive asymmetric lipid vesicle as drug carrier
AU - Zhang, Xunan
AU - Zong, Wei
AU - Hu, Ying
AU - Luo, Nan
AU - Cheng, Wenlong
AU - Han, Xiaojun
PY - 2016/10/2
Y1 - 2016/10/2
N2 - In order to increase the loading efficiency of drug carriers, here we demonstrated a microfluidic method to fabricate an asymmetric vesicle, which contains trichloro(1H,1H,2H,2H-perfluoroocty-l)silane (TPS) inner leaflet and lipid outer leaflet. The asymmetric vesicle was characterised by fluorescence microscopy and Fourier transform infra-red spectrum. In vitro cytotoxicity of the vesicles carrying 5-fluorouacil (5-FU) has also been studied.
AB - In order to increase the loading efficiency of drug carriers, here we demonstrated a microfluidic method to fabricate an asymmetric vesicle, which contains trichloro(1H,1H,2H,2H-perfluoroocty-l)silane (TPS) inner leaflet and lipid outer leaflet. The asymmetric vesicle was characterised by fluorescence microscopy and Fourier transform infra-red spectrum. In vitro cytotoxicity of the vesicles carrying 5-fluorouacil (5-FU) has also been studied.
KW - asymmetric vesicles
KW - drug delivery
KW - Lipid
KW - microfluidics
KW - self-assembly
UR - http://www.scopus.com/inward/record.url?scp=84992073654&partnerID=8YFLogxK
U2 - 10.1080/02652048.2016.1242668
DO - 10.1080/02652048.2016.1242668
M3 - Article
VL - 33
SP - 663
EP - 668
JO - Journal of Microencapsulation
JF - Journal of Microencapsulation
SN - 0265-2048
IS - 7
ER -