A Perspective Review on the Role of Nanomedicine in the Modulation of TNF-TNFR2 Axis in Breast Cancer Immunotherapy

Mohammad A.I. Al-Hatamleh, Suhana Ahmad, Jennifer C. Boer, Jitkang Lim, Xin Chen, Magdalena Plebanski, Rohimah Mohamud

Research output: Contribution to journalReview ArticleResearchpeer-review

28 Citations (Scopus)


In the past decade, nanomedicine research has provided us with highly useful agents (nanoparticles) delivering therapeutic drugs to target cancer cells. The present review highlights nanomedicine applications for breast cancer immunotherapy. Recent studies have suggested that tumour necrosis factor (TNF) and its receptor 2 (TNFR2) expressed on breast cancer cells have important functional consequences. This cytokine/receptor interaction is also critical for promoting highly immune-suppressive phenotypes by regulatory T cells (Tregs). This review generally provides a background for nanoparticles as potential drug delivery agents for immunomodulators and further discusses in depth the potential of TNF antagonists delivery to modulate TNF-TNFR2 interactions and inhibit breast cancer progression.

Original languageEnglish
Article number6313242
Number of pages14
JournalJournal of Oncology
Publication statusPublished - 1 Jan 2019

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