A pathogenic hierarchy for synovial fibroblasts in rheumatoid arthritis

Mohammed H. Abuwarwar; Konstantin Knoblich; Anne L. Fletcher

doi:10.21037/atm.2018.10.49

A pathogenic hierarchy for synovial fibroblasts in rheumatoid arthritis

Mohammed H. Abuwarwar, Konstantin Knoblich, Anne L. Fletcher

Research output: Contribution to journal › Editorial › Other

Abstract

Rheumatoid arthritis (RA) is a chronic autoimmune disorder that affects 0.5–1% of the world's population (1). It is characterized by inflammation and progressive destruction of joints (1). Synovial fibroblasts play important roles in initiating and driving RA by secreting inflammatory cytokines and chemokines, degrading cartilage, and stimulating osteoclasts that lead to bone erosion (2).

Original language	English
Number of pages	3
Journal	Annals of Translational Medicine
Volume	6
Issue number	Sup 1
DOIs	https://doi.org/10.21037/atm.2018.10.49
Publication status	Published - Nov 2018

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10.21037/atm.2018.10.49

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title = "A pathogenic hierarchy for synovial fibroblasts in rheumatoid arthritis",

abstract = "Rheumatoid arthritis (RA) is a chronic autoimmune disorder that affects 0.5–1\% of the world's population (1). It is characterized by inflammation and progressive destruction of joints (1). Synovial fibroblasts play important roles in initiating and driving RA by secreting inflammatory cytokines and chemokines, degrading cartilage, and stimulating osteoclasts that lead to bone erosion (2).",

author = "Abuwarwar, \{Mohammed H.\} and Konstantin Knoblich and Fletcher, \{Anne L.\}",

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AU - Abuwarwar, Mohammed H.

AU - Knoblich, Konstantin

AU - Fletcher, Anne L.

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N2 - Rheumatoid arthritis (RA) is a chronic autoimmune disorder that affects 0.5–1% of the world's population (1). It is characterized by inflammation and progressive destruction of joints (1). Synovial fibroblasts play important roles in initiating and driving RA by secreting inflammatory cytokines and chemokines, degrading cartilage, and stimulating osteoclasts that lead to bone erosion (2).

AB - Rheumatoid arthritis (RA) is a chronic autoimmune disorder that affects 0.5–1% of the world's population (1). It is characterized by inflammation and progressive destruction of joints (1). Synovial fibroblasts play important roles in initiating and driving RA by secreting inflammatory cytokines and chemokines, degrading cartilage, and stimulating osteoclasts that lead to bone erosion (2).

U2 - 10.21037/atm.2018.10.49

DO - 10.21037/atm.2018.10.49

M3 - Editorial

SN - 2305-5847

VL - 6

JO - Annals of Translational Medicine

JF - Annals of Translational Medicine

IS - Sup 1

ER -