A pathogenetic role for IL-21 in primary Sjogren syndrome

Seung-Ki Kwok, Jennifer Lee, Di Yu, Kwi Young Kang, Mi-La Cho, Hae-Rim Kim, Ji Hyeon Ju, Sang-Heon Lee, Sung-Hwan Park, Ho-Youn Kim

Research output: Contribution to journalArticleResearchpeer-review

34 Citations (Scopus)


Advances in our understanding of the pathogenesis of primary Sjogren syndrome (pSS) characterize it as a highly complex process encompassing both the initiation of innate immunity and subsequent adaptive immune responses. IL-21 is receiving attention as a potential key player in the pathogenesis of pSS owing to its pleiotropic effects on the type I interferon signalling pathway, and newly identified roles in generation of follicular and IL-17-producing subtypes of helper T cells, as well as plasma-cell differentiation and B-cell activation. Taking into consideration the diverse biological functions of IL-21 and its clinical relevance to pSS, we propose that this cytokine has a central role in orchestrating the complex immune response in pSS. This hypothesis might provide new insight into the pathogenesis of pSS and facilitate the development of effective therapeutic strategies.
Original languageEnglish
Pages (from-to)368 - 374
Number of pages7
JournalNature Reviews Rheumatology
Issue number6
Publication statusPublished - 2015

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