TY - JOUR
T1 - A one-pot, three-component, microwave-assisted synthesis of novel 7-amino-substituted 4-aminopyrazolo[1,5-a][1,3,5]triazine-8-carbonitriles
AU - Lim, Felicia Phei Lin
AU - Luna, Giuseppe
AU - Dolzhenko, Anton V
PY - 2015
Y1 - 2015
N2 - The synthesis of novel 7-amino-substituted pyrazolo[1,5-a][1,3,5]triazine-8-carbonitriles was achieved via a three-component reaction of 3-amino-substituted 5-aminopyrazole-4-carbonitriles, cyanamide and triethyl orthoformate under microwave irradiation. Under catalyst-free conditions, this three-component reaction accommodated a generous diversity of amino substituents making it ideal for the generation of compound libraries for drug discovery processes.
AB - The synthesis of novel 7-amino-substituted pyrazolo[1,5-a][1,3,5]triazine-8-carbonitriles was achieved via a three-component reaction of 3-amino-substituted 5-aminopyrazole-4-carbonitriles, cyanamide and triethyl orthoformate under microwave irradiation. Under catalyst-free conditions, this three-component reaction accommodated a generous diversity of amino substituents making it ideal for the generation of compound libraries for drug discovery processes.
UR - http://goo.gl/xhf6PU
U2 - 10.1016/j.tetlet.2015.11.006
DO - 10.1016/j.tetlet.2015.11.006
M3 - Article
SN - 0040-4039
VL - 56
SP - 7016
EP - 7019
JO - Tetrahedron Letters
JF - Tetrahedron Letters
IS - 50
ER -