A one-pot, three-component approach to functionalised tetrahydroisoquinolines using domino Heck?aza-Michael reactions

Daniel Priebbenow, Frederick Matthew Pfeffer, Scott G Stewart

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19 Citations (Scopus)

Abstract

A one-pot, three-component method incorporating a domino Heck?aza-Michael reaction has been developed for the rapid synthesis of functionalised tetrahydroisoquinolines. Following the in situ generation of an acrylamide, a domino process involving intermolecular Heck reaction and subsequentintramolecular aza-Michael addition affords tetrahydroisoquinolines bearing C1-acetamide functionality.
Original languageEnglish
Pages (from-to)1632 - 1635
Number of pages4
JournalEuropean Journal of Organic Chemistry
Volume2011
Issue number9
DOIs
Publication statusPublished - 2011
Externally publishedYes

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