A one-pot tandem synthesis of various 1,2-disubstituted benzimidazoles

Keng Yoon Yeong, Mohamed Ashraf Ali, Chee Wei Ang, Soo Choon Tan, Hasnah Osman

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11 Citations (Scopus)


A facile method to synthesize various 1,2-disubstituted benzimidazoles is developed. It is suggested that formation of a Meisenheimer adduct between the substrate, amine, and solvent aids the N-arylation process. The generality of the protocol is demonstrated by the efficient reactions involving numerous substituents ranging from electron-withdrawing groups to electron-donating groups.

Original languageEnglish
Pages (from-to)4697-4700
Number of pages4
JournalTetrahedron Letters
Issue number34
Publication statusPublished - 2014
Externally publishedYes


  • Cycloaddition
  • Substituted benzimidazoles
  • Tandem synthesis

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