A one-pot synthesis of N2,6-diaryl-5,6-dihydro-1,3,5-triazine-2,4-diamines and systematic evaluation of their ability to host ethanol in crystals

Ahmad Junaid, Anton V. Dolzhenko, Yee Seng Tan, Edward R.T. Tiekink

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    3 Citations (Scopus)


    A convenient one-pot method for the preparation of N2,6-diaryl-5,6-dihydro-1,3,5-triazine-2,4-diamines was developed using a three-component synthesis of 1,6-diaryl-1,6-dihydro-1,3,5-triazine-2,4-diamines followed by their Dimroth rearrangement to the desired products. The prepared compounds crystallized from ethanol as ethanol clathrates (1 : 1). X-ray crystallography on several products confirmed the adoption of 5,6-dihydro-tautomer. The thermal analysis and powder X-ray diffraction experiments on selected compounds suggested that thermal desolvation of crystals was irreversible.

    Original languageEnglish
    Pages (from-to)37660-37667
    Number of pages8
    JournalRSC Advances
    Issue number64
    Publication statusPublished - 18 Nov 2019

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