@article{9224805955394b60bc420d86ec8a0c61,
title = "A one-pot, multicomponent reaction for the synthesis of novel 2-alkyl substituted 4-aminoimidazo[1,2-a] [1,3,5]triazines",
abstract = "A highly selective, one-pot, three-component synthesis of novel 2-alkyl-substituted 4-aminoimidazo[1,2-a][1,3,5]triazines has been developed. The scope of the method was explored in two dimensions, varying the structures of trialkyl orthoesters and 2-aminoimidazoles in their reactions with cyanamide. Conveniently performed under microwave irradiation, this method was also proved to be efficient under conventional heating. A library of 24 novel compounds was prepared in high purity using this multicomponent approach. Molecular and crystal structures of representative molecules were studied using X-ray crystallography.",
author = "Lim, \{Felicia Phei Lin\} and Tan, \{Lin Yuing\} and Tiekink, \{Edward R.T.\} and Dolzhenko, \{Anton V.\}",
note = "Funding Information: This work is supported by the Ministry of Higher Education, Malaysia under Fundamental Research Grant Scheme (FRGS). We would like to thank Anton Paar Malaysia Sdn. Bhd. for their technical support. The Research Centre for Crystalline Materials (Sunway University) is thanked for the X-ray intensity data. Publisher Copyright: {\textcopyright} The Royal Society of Chemistry 2018. Copyright: Copyright 2018 Elsevier B.V., All rights reserved.",
year = "2018",
doi = "10.1039/c8ra03703e",
language = "English",
volume = "8",
pages = "21495--21504",
journal = "RSC Advances",
issn = "2046-2069",
publisher = "The Royal Society of Chemistry",
number = "38",
}