A novel type of dual-modality molecular probe for MR and nuclear imaging of tumor: Preparation, characterization and in vivo application

Shujie Liu, Bing Jia, Ruirui Qiao, Zhi Yang, Zilin Yu, Zhaofei Liu, Kan Liu, Jiyun Shi, Han Ouyang, Fan Wang, Mingyuan Gao

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Abstract

A novel dual-modality molecular probe composed of biocompatible Fe 3O4 nanocrystal, monoclonal antibody and radionuclide was designed and prepared. All functional components in the dual-modality molecular probe, i.e., Fe3O4, PEG, mAb 3H11 and 125I, were chemically bonded together for forming a stable molecular probe. Systematic in vitro experiments were carried out for evaluating the biological activity of the antibody in the targeting probe. A series of in vivo experiments were performed based on the dual-modality imaging probe for detecting xenografted tumors in nude mice by MRI and γ-imaging techniques. The pharmacokinetics of the dual-modality molecular probe in tumor-bearing nude mice was studied. 

Original languageEnglish
Pages (from-to)1074-1082
Number of pages9
JournalMolecular Pharmaceutics
Volume6
Issue number4
DOIs
Publication statusPublished - 3 Aug 2009
Externally publishedYes

Keywords

  • Dual-modality molecular probe
  • FeO nanocrystals
  • MRI
  • Nuclear imaging
  • Tumor

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