A novel ternary component for dry powder inhaler formulations

Shyamal Chandra Das, David Alexander Vodden Morton, Linh T Vu, James A Hourigan, Peter James Stewart

Research output: Chapter in Book/Report/Conference proceedingConference PaperResearchpeer-review


The concept of the ternary formulations was a major step in the development of dry powder inhaler formulation (1). The use of fine lactose as a ternary component is now well accepted to improve aerolization efficiency of mixtures (2). Pharmaceutical fine lactose is generally made by milling and sieving large tomahawk-shaped crystals of alpha lactose produced by batch cooling crystallization. A common problem associated with this milling process is the generation of amorphous domains which are prone to physical and chemical instability (3). Therefore, it is attractive to avoid amorphous lactose by instead controlling the crystallization to produce crystals of the desired particle size directly. In this study, fine lactose crystals have been produced by a proprietary process, and an initial investigation of their properties in the context of a ternary dry powder inhaler formulation is prepared.
Original languageEnglish
Title of host publicationRespiratory Drug Delivery 2009
EditorsRichard N Dalby, Peter R Byron, Joanne Peart, Julie D Suman, Paul M Young
Place of PublicationUSA
PublisherDavis Healthcare International Publishing
Pages327 - 332
Number of pages6
ISBN (Print)1933722312
Publication statusPublished - 2009
EventRespiratory Drug Delivery 2009 - Lisbon, Portugal, USA
Duration: 1 Jan 2009 → …


ConferenceRespiratory Drug Delivery 2009
Period1/01/09 → …

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