A novel platform to study platelet aggregation and thrombus growth based on micro strain-rate changes

F. J. Tovar-Lopez, G. Rosengarten, K. Khoshmanesh, S. P. Jackson, A. Mitchell, W. S. Nesbitt

Research output: Chapter in Book/Report/Conference proceedingConference PaperResearchpeer-review

Abstract

This paper reports the development of a platform for measuring platelet function and thrombus growth dynamics based on localized micro-strain rate gradients. Chemical and mechanical factors are critical in platelet aggregation but the mechaniccal factors are poorly understood. We present the design, hydrodynamic characterization and experimental results of a novel microvascular mimetic device that generates a controlled dynamic mechanical stress to induce localized platelet aggregation. This platform will have long term utility in the diagnosis of platelet functional defects in patients suffering from cardiovascular disease as well as utility as a screening platform of drugs targeting thrombosis induced by hemodynamic mechanisms.

Original languageEnglish
Title of host publicationProceedings of Conference, MicroTAS 2009 - The 13th International Conference on Miniaturized Systems for Chemistry and Life Sciences
PublisherChemical and Biological Microsystems Society
Pages1112-1114
Number of pages3
ISBN (Print)9780979806421
Publication statusPublished - 1 Jan 2009
Event13th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2009 - Jeju, Korea, Republic of (South)
Duration: 1 Nov 20095 Nov 2009

Conference

Conference13th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2009
CountryKorea, Republic of (South)
CityJeju
Period1/11/095/11/09

Keywords

  • Microfluidics
  • Platelet aggregation
  • Shear microgradient

Cite this

Tovar-Lopez, F. J., Rosengarten, G., Khoshmanesh, K., Jackson, S. P., Mitchell, A., & Nesbitt, W. S. (2009). A novel platform to study platelet aggregation and thrombus growth based on micro strain-rate changes. In Proceedings of Conference, MicroTAS 2009 - The 13th International Conference on Miniaturized Systems for Chemistry and Life Sciences (pp. 1112-1114). Chemical and Biological Microsystems Society.
Tovar-Lopez, F. J. ; Rosengarten, G. ; Khoshmanesh, K. ; Jackson, S. P. ; Mitchell, A. ; Nesbitt, W. S. / A novel platform to study platelet aggregation and thrombus growth based on micro strain-rate changes. Proceedings of Conference, MicroTAS 2009 - The 13th International Conference on Miniaturized Systems for Chemistry and Life Sciences. Chemical and Biological Microsystems Society, 2009. pp. 1112-1114
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keywords = "Microfluidics, Platelet aggregation, Shear microgradient",
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Tovar-Lopez, FJ, Rosengarten, G, Khoshmanesh, K, Jackson, SP, Mitchell, A & Nesbitt, WS 2009, A novel platform to study platelet aggregation and thrombus growth based on micro strain-rate changes. in Proceedings of Conference, MicroTAS 2009 - The 13th International Conference on Miniaturized Systems for Chemistry and Life Sciences. Chemical and Biological Microsystems Society, pp. 1112-1114, 13th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2009, Jeju, Korea, Republic of (South), 1/11/09.

A novel platform to study platelet aggregation and thrombus growth based on micro strain-rate changes. / Tovar-Lopez, F. J.; Rosengarten, G.; Khoshmanesh, K.; Jackson, S. P.; Mitchell, A.; Nesbitt, W. S.

Proceedings of Conference, MicroTAS 2009 - The 13th International Conference on Miniaturized Systems for Chemistry and Life Sciences. Chemical and Biological Microsystems Society, 2009. p. 1112-1114.

Research output: Chapter in Book/Report/Conference proceedingConference PaperResearchpeer-review

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AB - This paper reports the development of a platform for measuring platelet function and thrombus growth dynamics based on localized micro-strain rate gradients. Chemical and mechanical factors are critical in platelet aggregation but the mechaniccal factors are poorly understood. We present the design, hydrodynamic characterization and experimental results of a novel microvascular mimetic device that generates a controlled dynamic mechanical stress to induce localized platelet aggregation. This platform will have long term utility in the diagnosis of platelet functional defects in patients suffering from cardiovascular disease as well as utility as a screening platform of drugs targeting thrombosis induced by hemodynamic mechanisms.

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Tovar-Lopez FJ, Rosengarten G, Khoshmanesh K, Jackson SP, Mitchell A, Nesbitt WS. A novel platform to study platelet aggregation and thrombus growth based on micro strain-rate changes. In Proceedings of Conference, MicroTAS 2009 - The 13th International Conference on Miniaturized Systems for Chemistry and Life Sciences. Chemical and Biological Microsystems Society. 2009. p. 1112-1114