A novel mouse model of atherosclerotic plaque instability for drug testing and mechanistic/therapeutic discoveries using gene and microRNA expression profiling

Yung-Chih Chen; Anh Viet Bui; Jeannine Diesch; Richard Manasseh; Christian Hausding; Jennifer Rivera; Izhak Haviv; Alexander Agrotis; Nay Min Htun; Jeremy B M Jowett; Christoph E Hagemeyer; Ross Duncan Hannan; Alexander Bobik; Karlheinz Peter

doi:10.1161/CIRCRESAHA.113.301562

A novel mouse model of atherosclerotic plaque instability for drug testing and mechanistic/therapeutic discoveries using gene and microRNA expression profiling

Yung-Chih Chen, Anh Viet Bui, Jeannine Diesch, Richard Manasseh, Christian Hausding, Jennifer Rivera, Izhak Haviv, Alexander Agrotis, Nay Min Htun, Jeremy B M Jowett, Christoph E Hagemeyer, Ross Duncan Hannan, Alexander Bobik, Karlheinz Peter

Medicine Alfred Hospital

Research output: Contribution to journal › Article › Research › peer-review

184 Citations (Scopus)

Abstract

The high morbidity/mortality of atherosclerosis is typically precipitated by plaque rupture and consequent thrombosis. However, research on underlying mechanisms and therapeutic approaches is limited by the lack of animal models that reproduce plaque instability observed in humans. Objective: Development and use of a mouse model of plaque rupture that reflects the end stage of human atherosclerosis.

Original language	English
Pages (from-to)	252-265
Number of pages	14
Journal	Circulation Research
Volume	113
Issue number	3
DOIs	https://doi.org/10.1161/CIRCRESAHA.113.301562
Publication status	Published - 2013

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This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

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10.1161/CIRCRESAHA.113.301562

Cite this

Chen, Y.-C., Bui, A. V., Diesch, J., Manasseh, R., Hausding, C., Rivera, J., Haviv, I., Agrotis, A., Htun, N. M., Jowett, J. B. M., Hagemeyer, C. E., Hannan, R. D., Bobik, A., & Peter, K. (2013). A novel mouse model of atherosclerotic plaque instability for drug testing and mechanistic/therapeutic discoveries using gene and microRNA expression profiling. Circulation Research, 113(3), 252-265. https://doi.org/10.1161/CIRCRESAHA.113.301562

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abstract = "The high morbidity/mortality of atherosclerosis is typically precipitated by plaque rupture and consequent thrombosis. However, research on underlying mechanisms and therapeutic approaches is limited by the lack of animal models that reproduce plaque instability observed in humans. Objective: Development and use of a mouse model of plaque rupture that reflects the end stage of human atherosclerosis.",

author = "Yung-Chih Chen and Bui, \{Anh Viet\} and Jeannine Diesch and Richard Manasseh and Christian Hausding and Jennifer Rivera and Izhak Haviv and Alexander Agrotis and Htun, \{Nay Min\} and Jowett, \{Jeremy B M\} and Hagemeyer, \{Christoph E\} and Hannan, \{Ross Duncan\} and Alexander Bobik and Karlheinz Peter",

year = "2013",

doi = "10.1161/CIRCRESAHA.113.301562",

language = "English",

volume = "113",

pages = "252--265",

journal = "Circulation Research",

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Chen, Y-C, Bui, AV, Diesch, J, Manasseh, R, Hausding, C, Rivera, J, Haviv, I, Agrotis, A, Htun, NM, Jowett, JBM, Hagemeyer, CE, Hannan, RD, Bobik, A & Peter, K 2013, 'A novel mouse model of atherosclerotic plaque instability for drug testing and mechanistic/therapeutic discoveries using gene and microRNA expression profiling', Circulation Research, vol. 113, no. 3, pp. 252-265. https://doi.org/10.1161/CIRCRESAHA.113.301562

TY - JOUR

T1 - A novel mouse model of atherosclerotic plaque instability for drug testing and mechanistic/therapeutic discoveries using gene and microRNA expression profiling

AU - Chen, Yung-Chih

AU - Bui, Anh Viet

AU - Diesch, Jeannine

AU - Manasseh, Richard

AU - Hausding, Christian

AU - Rivera, Jennifer

AU - Haviv, Izhak

AU - Agrotis, Alexander

AU - Htun, Nay Min

AU - Jowett, Jeremy B M

AU - Hagemeyer, Christoph E

AU - Hannan, Ross Duncan

AU - Bobik, Alexander

AU - Peter, Karlheinz

PY - 2013

Y1 - 2013

N2 - The high morbidity/mortality of atherosclerosis is typically precipitated by plaque rupture and consequent thrombosis. However, research on underlying mechanisms and therapeutic approaches is limited by the lack of animal models that reproduce plaque instability observed in humans. Objective: Development and use of a mouse model of plaque rupture that reflects the end stage of human atherosclerosis.

AB - The high morbidity/mortality of atherosclerosis is typically precipitated by plaque rupture and consequent thrombosis. However, research on underlying mechanisms and therapeutic approaches is limited by the lack of animal models that reproduce plaque instability observed in humans. Objective: Development and use of a mouse model of plaque rupture that reflects the end stage of human atherosclerosis.

UR - http://www.ncbi.nlm.nih.gov/pubmed/23748430

UR - https://www.scopus.com/pages/publications/84880773545

U2 - 10.1161/CIRCRESAHA.113.301562

DO - 10.1161/CIRCRESAHA.113.301562

M3 - Article

SN - 0009-7330

VL - 113

SP - 252

EP - 265

JO - Circulation Research

JF - Circulation Research

IS - 3

ER -

A novel mouse model of atherosclerotic plaque instability for drug testing and mechanistic/therapeutic discoveries using gene and microRNA expression profiling

Abstract

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