A novel mouse model of atherosclerotic plaque instability for drug testing and mechanistic/therapeutic discoveries using gene and microRNA expression profiling

Yung-Chih Chen, Anh Viet Bui, Jeannine Diesch, Richard Manasseh, Christian Hausding, Jennifer Rivera, Izhak Haviv, Alexander Agrotis, Nay Min Htun, Jeremy B M Jowett, Christoph E Hagemeyer, Ross Duncan Hannan, Alexander Bobik, Karlheinz Peter

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94 Citations (Scopus)

Abstract

The high morbidity/mortality of atherosclerosis is typically precipitated by plaque rupture and consequent thrombosis. However, research on underlying mechanisms and therapeutic approaches is limited by the lack of animal models that reproduce plaque instability observed in humans. Objective: Development and use of a mouse model of plaque rupture that reflects the end stage of human atherosclerosis.
Original languageEnglish
Pages (from-to)252 - 265
Number of pages14
JournalCirculation Research
Volume113
Issue number3
DOIs
Publication statusPublished - 2013

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