A novel mouse model of atherosclerotic plaque instability for drug testing and mechanistic/therapeutic discoveries using gene and microRNA expression profiling

Yung-Chih Chen, Anh Viet Bui, Jeannine Diesch, Richard Manasseh, Christian Hausding, Jennifer Rivera, Izhak Haviv, Alexander Agrotis, Nay Min Htun, Jeremy B M Jowett, Christoph E Hagemeyer, Ross Duncan Hannan, Alexander Bobik, Karlheinz Peter

Research output: Contribution to journalArticleResearchpeer-review

Abstract

The high morbidity/mortality of atherosclerosis is typically precipitated by plaque rupture and consequent thrombosis. However, research on underlying mechanisms and therapeutic approaches is limited by the lack of animal models that reproduce plaque instability observed in humans. Objective: Development and use of a mouse model of plaque rupture that reflects the end stage of human atherosclerosis.
Original languageEnglish
Pages (from-to)252 - 265
Number of pages14
JournalCirculation Research
Volume113
Issue number3
DOIs
Publication statusPublished - 2013

Cite this

Chen, Yung-Chih ; Bui, Anh Viet ; Diesch, Jeannine ; Manasseh, Richard ; Hausding, Christian ; Rivera, Jennifer ; Haviv, Izhak ; Agrotis, Alexander ; Htun, Nay Min ; Jowett, Jeremy B M ; Hagemeyer, Christoph E ; Hannan, Ross Duncan ; Bobik, Alexander ; Peter, Karlheinz. / A novel mouse model of atherosclerotic plaque instability for drug testing and mechanistic/therapeutic discoveries using gene and microRNA expression profiling. In: Circulation Research. 2013 ; Vol. 113, No. 3. pp. 252 - 265.
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abstract = "The high morbidity/mortality of atherosclerosis is typically precipitated by plaque rupture and consequent thrombosis. However, research on underlying mechanisms and therapeutic approaches is limited by the lack of animal models that reproduce plaque instability observed in humans. Objective: Development and use of a mouse model of plaque rupture that reflects the end stage of human atherosclerosis.",
author = "Yung-Chih Chen and Bui, {Anh Viet} and Jeannine Diesch and Richard Manasseh and Christian Hausding and Jennifer Rivera and Izhak Haviv and Alexander Agrotis and Htun, {Nay Min} and Jowett, {Jeremy B M} and Hagemeyer, {Christoph E} and Hannan, {Ross Duncan} and Alexander Bobik and Karlheinz Peter",
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A novel mouse model of atherosclerotic plaque instability for drug testing and mechanistic/therapeutic discoveries using gene and microRNA expression profiling. / Chen, Yung-Chih; Bui, Anh Viet; Diesch, Jeannine; Manasseh, Richard; Hausding, Christian; Rivera, Jennifer; Haviv, Izhak; Agrotis, Alexander; Htun, Nay Min; Jowett, Jeremy B M; Hagemeyer, Christoph E; Hannan, Ross Duncan; Bobik, Alexander; Peter, Karlheinz.

In: Circulation Research, Vol. 113, No. 3, 2013, p. 252 - 265.

Research output: Contribution to journalArticleResearchpeer-review

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T1 - A novel mouse model of atherosclerotic plaque instability for drug testing and mechanistic/therapeutic discoveries using gene and microRNA expression profiling

AU - Chen, Yung-Chih

AU - Bui, Anh Viet

AU - Diesch, Jeannine

AU - Manasseh, Richard

AU - Hausding, Christian

AU - Rivera, Jennifer

AU - Haviv, Izhak

AU - Agrotis, Alexander

AU - Htun, Nay Min

AU - Jowett, Jeremy B M

AU - Hagemeyer, Christoph E

AU - Hannan, Ross Duncan

AU - Bobik, Alexander

AU - Peter, Karlheinz

PY - 2013

Y1 - 2013

N2 - The high morbidity/mortality of atherosclerosis is typically precipitated by plaque rupture and consequent thrombosis. However, research on underlying mechanisms and therapeutic approaches is limited by the lack of animal models that reproduce plaque instability observed in humans. Objective: Development and use of a mouse model of plaque rupture that reflects the end stage of human atherosclerosis.

AB - The high morbidity/mortality of atherosclerosis is typically precipitated by plaque rupture and consequent thrombosis. However, research on underlying mechanisms and therapeutic approaches is limited by the lack of animal models that reproduce plaque instability observed in humans. Objective: Development and use of a mouse model of plaque rupture that reflects the end stage of human atherosclerosis.

UR - http://www.ncbi.nlm.nih.gov/pubmed/23748430

U2 - 10.1161/CIRCRESAHA.113.301562

DO - 10.1161/CIRCRESAHA.113.301562

M3 - Article

VL - 113

SP - 252

EP - 265

JO - Circulation Research

JF - Circulation Research

SN - 0009-7330

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