A novel flavin derivative reveals the impact of glucose on oxidative stress in adipocytes

Jonathan Yeow; Amandeep Kaur; Matthew D. Anscomb; Elizabeth J. New

doi:10.1039/c4cc03464c

A novel flavin derivative reveals the impact of glucose on oxidative stress in adipocytes

Jonathan Yeow, Amandeep Kaur, Matthew D. Anscomb, Elizabeth J. New

Research output: Contribution to journal › Article › Research › peer-review

31 Citations (Scopus)

Abstract

We present the synthesis and characterisation of naphthalimide-flavin redox sensor 1 (NpFR1), a novel flavin molecule that is almost non-fluorescent in reduced form, but oxidation gives rise to a 125-fold increase in fluorescence. Confocal microscopy experiments confirm that NpFR1 is sensitive to redox changes within living cells.

Original language	English
Pages (from-to)	8181-8184
Number of pages	4
Journal	Chemical Communications
Volume	50
Issue number	60
DOIs	https://doi.org/10.1039/c4cc03464c
Publication status	Published - 1 Jul 2014
Externally published	Yes

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10.1039/c4cc03464cLicence: CC BY

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title = "A novel flavin derivative reveals the impact of glucose on oxidative stress in adipocytes",

abstract = "We present the synthesis and characterisation of naphthalimide-flavin redox sensor 1 (NpFR1), a novel flavin molecule that is almost non-fluorescent in reduced form, but oxidation gives rise to a 125-fold increase in fluorescence. Confocal microscopy experiments confirm that NpFR1 is sensitive to redox changes within living cells.",

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AB - We present the synthesis and characterisation of naphthalimide-flavin redox sensor 1 (NpFR1), a novel flavin molecule that is almost non-fluorescent in reduced form, but oxidation gives rise to a 125-fold increase in fluorescence. Confocal microscopy experiments confirm that NpFR1 is sensitive to redox changes within living cells.

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JO - Chemical Communications

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A novel flavin derivative reveals the impact of glucose on oxidative stress in adipocytes

Abstract

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