A novel correlation for protein diffusion coefficients based on molecular weight and radius of gyration

Lizhong He, Bernd Niemeyer

Research output: Contribution to journalArticleResearchpeer-review

100 Citations (Scopus)

Abstract

A new correlation is proposed for the prediction of protein diffusion coefficients in free solution. Molecular weight and radius of gyration of proteins are employed as correlation parameters in this method. Both parameters can be easily found in the literature. The correlation works well for diverse proteins with different shapes and extensive molecular weight. Furthermore, this method does not require a preassumption regarding the protein shape while it offers a rapid and convenient calculation with a high accuracy. Also, the proposed correlation can elucidate the estimation deviation of previous correlation methods in the literature.

Original languageEnglish
Pages (from-to)544-548
Number of pages5
JournalBiotechnology Progress
Volume19
Issue number2
DOIs
Publication statusPublished - 1 Mar 2003

Cite this

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abstract = "A new correlation is proposed for the prediction of protein diffusion coefficients in free solution. Molecular weight and radius of gyration of proteins are employed as correlation parameters in this method. Both parameters can be easily found in the literature. The correlation works well for diverse proteins with different shapes and extensive molecular weight. Furthermore, this method does not require a preassumption regarding the protein shape while it offers a rapid and convenient calculation with a high accuracy. Also, the proposed correlation can elucidate the estimation deviation of previous correlation methods in the literature.",
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A novel correlation for protein diffusion coefficients based on molecular weight and radius of gyration. / He, Lizhong; Niemeyer, Bernd.

In: Biotechnology Progress, Vol. 19, No. 2, 01.03.2003, p. 544-548.

Research output: Contribution to journalArticleResearchpeer-review

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