A novel approach to the regioselective synthesis of a disulfide-linked heterodimeric bicyclic peptide mimetic of brain-derived neurotrophic factor

Jordan M. Fletcher; Richard A. Hughes

doi:10.1016/j.tetlet.2004.08.002

A novel approach to the regioselective synthesis of a disulfide-linked heterodimeric bicyclic peptide mimetic of brain-derived neurotrophic factor

Jordan M. Fletcher
, Richard A. Hughes

Research output: Contribution to journal › Article › Research › peer-review

23 Citations (Scopus)

Abstract

We report a method for the regioselective synthesis of a disulfide-linked heterodimeric bicyclic peptide using a novel acetamidomethyl to S-pyridinyl exchange.

Original language	English
Pages (from-to)	6999-7001
Number of pages	3
Journal	Tetrahedron Letters
Volume	45
Issue number	38
DOIs	https://doi.org/10.1016/j.tetlet.2004.08.002
Publication status	Published - 13 Sept 2004
Externally published	Yes

Keywords

BDNF
Bicyclic
Dimerisation
Dipyridyl disulfide
Disulfide
Heterodimer
Peptide

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10.1016/j.tetlet.2004.08.002

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title = "A novel approach to the regioselective synthesis of a disulfide-linked heterodimeric bicyclic peptide mimetic of brain-derived neurotrophic factor",

abstract = "We report a method for the regioselective synthesis of a disulfide-linked heterodimeric bicyclic peptide using a novel acetamidomethyl to S-pyridinyl exchange.",

keywords = "BDNF, Bicyclic, Dimerisation, Dipyridyl disulfide, Disulfide, Heterodimer, Peptide",

author = "Fletcher, \{Jordan M.\} and Hughes, \{Richard A.\}",

year = "2004",

month = sep,

day = "13",

doi = "10.1016/j.tetlet.2004.08.002",

language = "English",

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journal = "Tetrahedron Letters",

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T1 - A novel approach to the regioselective synthesis of a disulfide-linked heterodimeric bicyclic peptide mimetic of brain-derived neurotrophic factor

AU - Fletcher, Jordan M.

AU - Hughes, Richard A.

PY - 2004/9/13

Y1 - 2004/9/13

N2 - We report a method for the regioselective synthesis of a disulfide-linked heterodimeric bicyclic peptide using a novel acetamidomethyl to S-pyridinyl exchange.

AB - We report a method for the regioselective synthesis of a disulfide-linked heterodimeric bicyclic peptide using a novel acetamidomethyl to S-pyridinyl exchange.

KW - BDNF

KW - Bicyclic

KW - Dimerisation

KW - Dipyridyl disulfide

KW - Disulfide

KW - Heterodimer

KW - Peptide

UR - https://www.scopus.com/pages/publications/4444323608

U2 - 10.1016/j.tetlet.2004.08.002

DO - 10.1016/j.tetlet.2004.08.002

M3 - Article

AN - SCOPUS:4444323608

SN - 0040-4039

VL - 45

SP - 6999

EP - 7001

JO - Tetrahedron Letters

JF - Tetrahedron Letters

IS - 38

ER -

A novel approach to the regioselective synthesis of a disulfide-linked heterodimeric bicyclic peptide mimetic of brain-derived neurotrophic factor

Abstract

Keywords

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