A novel approach to the assessment of variations in the human platelet count

Michael F. Buckley; John W. James; Dianne E. Brown; Gordon S. Whyte; Mark G. Dean; Colin N. Chesterman; Jennifer A. Donald

A novel approach to the assessment of variations in the human platelet count

Michael F. Buckley, John W. James, Dianne E. Brown, Gordon S. Whyte, Mark G. Dean, Colin N. Chesterman, Jennifer A. Donald

Research output: Contribution to journal › Article › Research › peer-review

90 Citations (Scopus)

Abstract

This is the first report of a method to assess the significance of numerical changes in the platelet count based upon a result exceeding the normal intra-individual variation in platelet numbers. Serial platelet counts from 3789 subjects were analysed to determine the intra-individual variation in platelet numbers. A platelet count difference of 98 x 10⁹/L in males was found to represent a change that would occur by chance in less than 1 in 1000 platelet count determinations. Tables to determine the significance of platelet number variations, given N previous observations, are provided at two probability levels. The repeatability of the platelet count was calculated as 0.871 (males) and 0.849 (females) indicating that the heritability of platelet count is high and that the platelet count is predominantly genetically determined. A seasonal variation in platelet count was found with a 'winter' versus 'summer' difference of 5.10 x 10⁹/L (males) and 5.82 x 10⁹/L (females).

Original language	English
Pages (from-to)	480-484
Number of pages	5
Journal	Thrombosis and Haemostasis
Volume	83
Issue number	3
Publication status	Published - 25 Mar 2000
Externally published	Yes

Keywords

Genetics
Hematology
Heritability
Platelet count
Platelets

Cite this

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title = "A novel approach to the assessment of variations in the human platelet count",

abstract = "This is the first report of a method to assess the significance of numerical changes in the platelet count based upon a result exceeding the normal intra-individual variation in platelet numbers. Serial platelet counts from 3789 subjects were analysed to determine the intra-individual variation in platelet numbers. A platelet count difference of 98 x 109/L in males was found to represent a change that would occur by chance in less than 1 in 1000 platelet count determinations. Tables to determine the significance of platelet number variations, given N previous observations, are provided at two probability levels. The repeatability of the platelet count was calculated as 0.871 (males) and 0.849 (females) indicating that the heritability of platelet count is high and that the platelet count is predominantly genetically determined. A seasonal variation in platelet count was found with a 'winter' versus 'summer' difference of 5.10 x 109/L (males) and 5.82 x 109/L (females).",

keywords = "Genetics, Hematology, Heritability, Platelet count, Platelets",

author = "Buckley, {Michael F.} and James, {John W.} and Brown, {Dianne E.} and Whyte, {Gordon S.} and Dean, {Mark G.} and Chesterman, {Colin N.} and Donald, {Jennifer A.}",

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language = "English",

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pages = "480--484",

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TY - JOUR

T1 - A novel approach to the assessment of variations in the human platelet count

AU - Buckley, Michael F.

AU - James, John W.

AU - Brown, Dianne E.

AU - Whyte, Gordon S.

AU - Dean, Mark G.

AU - Chesterman, Colin N.

AU - Donald, Jennifer A.

PY - 2000/3/25

Y1 - 2000/3/25

N2 - This is the first report of a method to assess the significance of numerical changes in the platelet count based upon a result exceeding the normal intra-individual variation in platelet numbers. Serial platelet counts from 3789 subjects were analysed to determine the intra-individual variation in platelet numbers. A platelet count difference of 98 x 109/L in males was found to represent a change that would occur by chance in less than 1 in 1000 platelet count determinations. Tables to determine the significance of platelet number variations, given N previous observations, are provided at two probability levels. The repeatability of the platelet count was calculated as 0.871 (males) and 0.849 (females) indicating that the heritability of platelet count is high and that the platelet count is predominantly genetically determined. A seasonal variation in platelet count was found with a 'winter' versus 'summer' difference of 5.10 x 109/L (males) and 5.82 x 109/L (females).

AB - This is the first report of a method to assess the significance of numerical changes in the platelet count based upon a result exceeding the normal intra-individual variation in platelet numbers. Serial platelet counts from 3789 subjects were analysed to determine the intra-individual variation in platelet numbers. A platelet count difference of 98 x 109/L in males was found to represent a change that would occur by chance in less than 1 in 1000 platelet count determinations. Tables to determine the significance of platelet number variations, given N previous observations, are provided at two probability levels. The repeatability of the platelet count was calculated as 0.871 (males) and 0.849 (females) indicating that the heritability of platelet count is high and that the platelet count is predominantly genetically determined. A seasonal variation in platelet count was found with a 'winter' versus 'summer' difference of 5.10 x 109/L (males) and 5.82 x 109/L (females).

KW - Genetics

KW - Hematology

KW - Heritability

KW - Platelet count

KW - Platelets

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M3 - Article

C2 - 10744157

AN - SCOPUS:0034100760

VL - 83

SP - 480

EP - 484

JO - Thrombosis and Haemostasis

JF - Thrombosis and Haemostasis

SN - 0340-6245

IS - 3

ER -

A novel approach to the assessment of variations in the human platelet count

Abstract

Keywords

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