A note on simulating null distributions for G matrix comparisons

Michael B. Morrissey, Sandra Hangartner, Keyne Monro

Research output: Contribution to journalArticleResearchpeer-review

1 Citation (Scopus)

Abstract

Genetic variances and covariances, summarized in G matrices, are key determinants of the course of adaptive evolution. Consequently, understanding how G matrices vary among populations is critical to answering a variety of questions in evolutionary biology. A method has recently been proposed for generating null distributions of statistics pertaining to differences in G matrices among populations. The general approach facilitated by this method is likely to prove to be very important in studies of the evolution of G. We have identified an issue in the method that will cause it to create null distributions of differences in G matrices that are likely to be far too narrow. The issue arises from the fact that the method as currently used generates null distributions of statistics pertaining to differences in G matrices across populations by simulating breeding value vectors based on G matrices estimated from data, randomizing these vectors across populations, and then calculating null values of statistics from G matrices that are calculated directly from the variances and covariances among randomized vectors. This calculation treats breeding values as quantities that are directly measurable, instead of predicted from G matrices that are themselves estimated from patterns of covariance among kin. The existing method thus neglects a major source of uncertainty in G matrices, which renders it anti-conservative. We first suggest a correction to the method. We then apply the original and modified methods to a very simple instructive scenario. Finally, we demonstrate the use of both methods in the analysis of a real data set.

Original languageEnglish
Pages (from-to)2512-2517
Number of pages6
JournalEvolution
Volume73
Issue number12
DOIs
Publication statusPublished - Dec 2019

Keywords

  • Differentiation
  • G matrix
  • null distribution
  • quantitative genetics
  • tensor analysis

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