A new tool for quantifying and characterizing asymmetry in bilaterally paired structures

S M Rolfe, E D Camci, E Mercan, L G Shapiro, Timothy Chilton Cox

Research output: Chapter in Book/Report/Conference proceedingConference PaperResearchpeer-review

6 Citations (Scopus)


This paper introduces a new tool to quantify and characterize asymmetry in bilaterally paired structures. This method uses deformable registration to produce a dense vector field describing the point correspondences between two images of bilaterally paired structures. The deformation vector field properties are clustered to detect and describe regions of relevant asymmetry. Three methods are provided to analyze the asymmetries: the global asymmetry score uses cluster features to quantify overall asymmetry, the local asymmetry score quantifies asymmetry in user-defined regions of interest, and the asymmetry similarity measure quantifies pairwise similarity of individual asymmetry. The scores and image distances generated by this tool are shown to correlate highly with asymmetry ratings assigned by an expert.
Original languageEnglish
Title of host publicationIEEE Engineering in Medicine and Biology Society. Conference Proceedings
EditorsYoshitaka Hirooka
Place of PublicationUnited States
PublisherIEEE, Institute of Electrical and Electronics Engineers
Pages2364 - 2367
Number of pages4
ISBN (Print)1557-170X
Publication statusPublished - 2013
EventInternational Conference of the IEEE Engineering in Medicine and Biology Society 2013 - Osaka International Convention Center, Osaka, Japan
Duration: 3 Jul 20137 Jul 2013
Conference number: 35th


ConferenceInternational Conference of the IEEE Engineering in Medicine and Biology Society 2013
Abbreviated titleEMBC 2013

Cite this