A new tool for quantifying and characterizing asymmetry in bilaterally paired structures

S M Rolfe; E D Camci; E Mercan; L G Shapiro; Timothy Chilton Cox

doi:10.1109/EMBC.2013.6610013

A new tool for quantifying and characterizing asymmetry in bilaterally paired structures

S M Rolfe, E D Camci, E Mercan, L G Shapiro, Timothy Chilton Cox

Anatomy & Developmental Biology

Research output: Chapter in Book/Report/Conference proceeding › Conference Paper › Research › peer-review

6 Citations (Scopus)

Abstract

This paper introduces a new tool to quantify and characterize asymmetry in bilaterally paired structures. This method uses deformable registration to produce a dense vector field describing the point correspondences between two images of bilaterally paired structures. The deformation vector field properties are clustered to detect and describe regions of relevant asymmetry. Three methods are provided to analyze the asymmetries: the global asymmetry score uses cluster features to quantify overall asymmetry, the local asymmetry score quantifies asymmetry in user-defined regions of interest, and the asymmetry similarity measure quantifies pairwise similarity of individual asymmetry. The scores and image distances generated by this tool are shown to correlate highly with asymmetry ratings assigned by an expert.

Original language	English
Title of host publication	IEEE Engineering in Medicine and Biology Society. Conference Proceedings
Editors	Yoshitaka Hirooka
Place of Publication	United States
Publisher	IEEE, Institute of Electrical and Electronics Engineers
Pages	2364 - 2367
Number of pages	4
Volume	2013
ISBN (Print)	1557-170X
DOIs	https://doi.org/10.1109/EMBC.2013.6610013
Publication status	Published - 2013
Event	International Conference of the IEEE Engineering in Medicine and Biology Society 2013 - Osaka International Convention Center, Osaka, Japan Duration: 3 Jul 2013 → 7 Jul 2013 Conference number: 35th

Conference

Conference	International Conference of the IEEE Engineering in Medicine and Biology Society 2013
Abbreviated title	EMBC 2013
Country	Japan
City	Osaka
Period	3/07/13 → 7/07/13

Access to Document

10.1109/EMBC.2013.6610013

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Cite this

Rolfe, S. M., Camci, E. D., Mercan, E., Shapiro, L. G., & Cox, T. C. (2013). A new tool for quantifying and characterizing asymmetry in bilaterally paired structures. In Y. Hirooka (Ed.), IEEE Engineering in Medicine and Biology Society. Conference Proceedings (Vol. 2013, pp. 2364 - 2367). IEEE, Institute of Electrical and Electronics Engineers. https://doi.org/10.1109/EMBC.2013.6610013

Rolfe, S M ; Camci, E D ; Mercan, E ; Shapiro, L G ; Cox, Timothy Chilton. / A new tool for quantifying and characterizing asymmetry in bilaterally paired structures. IEEE Engineering in Medicine and Biology Society. Conference Proceedings. editor / Yoshitaka Hirooka. Vol. 2013 United States : IEEE, Institute of Electrical and Electronics Engineers, 2013. pp. 2364 - 2367

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title = "A new tool for quantifying and characterizing asymmetry in bilaterally paired structures",

abstract = "This paper introduces a new tool to quantify and characterize asymmetry in bilaterally paired structures. This method uses deformable registration to produce a dense vector field describing the point correspondences between two images of bilaterally paired structures. The deformation vector field properties are clustered to detect and describe regions of relevant asymmetry. Three methods are provided to analyze the asymmetries: the global asymmetry score uses cluster features to quantify overall asymmetry, the local asymmetry score quantifies asymmetry in user-defined regions of interest, and the asymmetry similarity measure quantifies pairwise similarity of individual asymmetry. The scores and image distances generated by this tool are shown to correlate highly with asymmetry ratings assigned by an expert.",

author = "Rolfe, {S M} and Camci, {E D} and E Mercan and Shapiro, {L G} and Cox, {Timothy Chilton}",

year = "2013",

doi = "10.1109/EMBC.2013.6610013",

language = "English",

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editor = "Yoshitaka Hirooka",

booktitle = "IEEE Engineering in Medicine and Biology Society. Conference Proceedings",

publisher = "IEEE, Institute of Electrical and Electronics Engineers",

address = "United States of America",

note = "International Conference of the IEEE Engineering in Medicine and Biology Society 2013, EMBC 2013 ; Conference date: 03-07-2013 Through 07-07-2013",

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Rolfe, SM, Camci, ED, Mercan, E, Shapiro, LG & Cox, TC 2013, A new tool for quantifying and characterizing asymmetry in bilaterally paired structures. in Y Hirooka (ed.), IEEE Engineering in Medicine and Biology Society. Conference Proceedings. vol. 2013, IEEE, Institute of Electrical and Electronics Engineers, United States, pp. 2364 - 2367, International Conference of the IEEE Engineering in Medicine and Biology Society 2013, Osaka, Japan, 3/07/13. https://doi.org/10.1109/EMBC.2013.6610013

A new tool for quantifying and characterizing asymmetry in bilaterally paired structures. / Rolfe, S M; Camci, E D; Mercan, E; Shapiro, L G; Cox, Timothy Chilton.

IEEE Engineering in Medicine and Biology Society. Conference Proceedings. ed. / Yoshitaka Hirooka. Vol. 2013 United States : IEEE, Institute of Electrical and Electronics Engineers, 2013. p. 2364 - 2367.

Research output: Chapter in Book/Report/Conference proceeding › Conference Paper › Research › peer-review

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N2 - This paper introduces a new tool to quantify and characterize asymmetry in bilaterally paired structures. This method uses deformable registration to produce a dense vector field describing the point correspondences between two images of bilaterally paired structures. The deformation vector field properties are clustered to detect and describe regions of relevant asymmetry. Three methods are provided to analyze the asymmetries: the global asymmetry score uses cluster features to quantify overall asymmetry, the local asymmetry score quantifies asymmetry in user-defined regions of interest, and the asymmetry similarity measure quantifies pairwise similarity of individual asymmetry. The scores and image distances generated by this tool are shown to correlate highly with asymmetry ratings assigned by an expert.

AB - This paper introduces a new tool to quantify and characterize asymmetry in bilaterally paired structures. This method uses deformable registration to produce a dense vector field describing the point correspondences between two images of bilaterally paired structures. The deformation vector field properties are clustered to detect and describe regions of relevant asymmetry. Three methods are provided to analyze the asymmetries: the global asymmetry score uses cluster features to quantify overall asymmetry, the local asymmetry score quantifies asymmetry in user-defined regions of interest, and the asymmetry similarity measure quantifies pairwise similarity of individual asymmetry. The scores and image distances generated by this tool are shown to correlate highly with asymmetry ratings assigned by an expert.

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BT - IEEE Engineering in Medicine and Biology Society. Conference Proceedings

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Rolfe SM, Camci ED, Mercan E, Shapiro LG, Cox TC. A new tool for quantifying and characterizing asymmetry in bilaterally paired structures. In Hirooka Y, editor, IEEE Engineering in Medicine and Biology Society. Conference Proceedings. Vol. 2013. United States: IEEE, Institute of Electrical and Electronics Engineers. 2013. p. 2364 - 2367 https://doi.org/10.1109/EMBC.2013.6610013