TY - JOUR
T1 - A new synthesis of the benzofuran adenosine antagonist XH-14
AU - Hutchinson, Sally A.
AU - Luetjens, Henning
AU - Scammells, Peter J.
PY - 1997/12/16
Y1 - 1997/12/16
N2 - 5-(3-Hydroxypropyl)-7-methoxy-2-(3'-methoxy-4'-hydroxyphenyl)benzo[b]furan-3 -carbaldehyde (XH-14, 1) has been reported to be a potent A1adenosine antagonist. We have developed an efficient synthesis of this compound that should prove valuable for further structure-activity studies. The synthesis incorporates optimised methodology for the selective protection of a hydroxyl group and the ortho-bromination of a phenol.
AB - 5-(3-Hydroxypropyl)-7-methoxy-2-(3'-methoxy-4'-hydroxyphenyl)benzo[b]furan-3 -carbaldehyde (XH-14, 1) has been reported to be a potent A1adenosine antagonist. We have developed an efficient synthesis of this compound that should prove valuable for further structure-activity studies. The synthesis incorporates optimised methodology for the selective protection of a hydroxyl group and the ortho-bromination of a phenol.
UR - http://www.scopus.com/inward/record.url?scp=0031454605&partnerID=8YFLogxK
U2 - 10.1016/S0960-894X(97)10173-1
DO - 10.1016/S0960-894X(97)10173-1
M3 - Article
AN - SCOPUS:0031454605
SN - 0960-894X
VL - 7
SP - 3081
EP - 3084
JO - Bioorganic and Medicinal Chemistry Letters
JF - Bioorganic and Medicinal Chemistry Letters
IS - 24
ER -