A new synthesis of phosphoramidates: inhibitors of the key bacterial enzyme aspartate semi-aldehyde dehydrogenase

Luke A. Adams, Russell J. Cox, Jennifer S. Gibson, M. Belén Mayo-Martín, Magnus Walter, William Whittingham

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27 Citations (Scopus)

Abstract

A new, mild and high yielding synthesis of phosphoramidates is described: potassium salts of carboxylic acids are treated with ethylchloroformate and the resulting activated anhydride-carbonates are then treated with LiNHP(O)(OEt)2 in situ—the methodology is especially suited to acid sensitive systems featuring BOC,tBu or acetal protecting groups.

Original languageEnglish
Pages (from-to)2004-2005
Number of pages2
JournalChemical Communications
Volume2
Issue number18
DOIs
Publication statusPublished - 1 Jan 2002
Externally publishedYes

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