A new stereospecific route to α-alkylidene γ-lactones

W. Roy Jackson; Patrick Perlmutter; Andrew J. Smallridge

doi:10.1039/C39850001509

A new stereospecific route to α-alkylidene γ-lactones

W. Roy Jackson, Patrick Perlmutter, Andrew J. Smallridge

School of Chemistry

Research output: Contribution to journal › Article › Research › peer-review

4 Citations (Scopus)

Abstract

Hydrocyanation of a range of protected β-hydroxyalkynes gives unsaturated nitriles which can be cyclised to α-alkylidene γ-lactones and in most cases the regioselectivity of hydrocyanation can be controlled giving the desired cyanoalkenes with stereospecific formation of the E-isomer.

Original language	English
Pages (from-to)	1509-1510
Number of pages	2
Journal	Journal of the Chemical Society, Chemical Communications
Issue number	21
DOIs	https://doi.org/10.1039/C39850001509
Publication status	Published - 1 Jan 1985

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10.1039/C39850001509

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Cite this

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title = "A new stereospecific route to α-alkylidene γ-lactones",

abstract = "Hydrocyanation of a range of protected β-hydroxyalkynes gives unsaturated nitriles which can be cyclised to α-alkylidene γ-lactones and in most cases the regioselectivity of hydrocyanation can be controlled giving the desired cyanoalkenes with stereospecific formation of the E-isomer.",

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AB - Hydrocyanation of a range of protected β-hydroxyalkynes gives unsaturated nitriles which can be cyclised to α-alkylidene γ-lactones and in most cases the regioselectivity of hydrocyanation can be controlled giving the desired cyanoalkenes with stereospecific formation of the E-isomer.

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