A new stereospecific route to α-alkylidene γ-lactones

W. Roy Jackson, Patrick Perlmutter, Andrew J. Smallridge

Research output: Contribution to journalArticleResearchpeer-review

4 Citations (Scopus)


Hydrocyanation of a range of protected β-hydroxyalkynes gives unsaturated nitriles which can be cyclised to α-alkylidene γ-lactones and in most cases the regioselectivity of hydrocyanation can be controlled giving the desired cyanoalkenes with stereospecific formation of the E-isomer.

Original languageEnglish
Pages (from-to)1509-1510
Number of pages2
JournalJournal of the Chemical Society, Chemical Communications
Issue number21
Publication statusPublished - 1 Jan 1985

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