A new sol–gel process for producing Na2O-containing bioactive glass ceramics

Qizhi Chen, Yuan Li, Liyu Jin, Julian Michael Warner Quinn, Paul Komesaroff

Research output: Contribution to journalArticleResearchpeer-review

Abstract

The sol–gel process of producing SiO2–CaO bioactive glasses is well established, but problems remain with the poor mechanical properties of the amorphous form and the bioinertness of its crystalline counterpart. These properties may be improved by incorporating Na2O into bioactive glasses, which can result in the formation of a hard yet biodegradable crystalline phase from bioactive glasses when sintered. However, production of Na2O-containing bioactive glasses by sol–gel methods has proved to be difficult. This work reports a new sol–gel process for the production of Na2O-containing bioactive glass ceramics, potentially enabling their use as medical implantation materials. Fine powders of 45S5 (a Na2O-containing composition) glass ceramic have for the first time been successfully synthesized using the sol–gel technique in aqueous solution under ambient conditions, with the mean particle size being ∼5 μm. A comparative study of sol–gel derived S70C30 (a Na2O-free composition) and 45S5 glass ceramic materials revealed that the latter possesses a number of features desirable in biomaterials used for bone tissue engineering, including (i) the crystalline phase Na2Ca2Si3O9 that couples good mechanical strength with satisfactory biodegradability, (ii) formation of hydroxyapatite, which may promote good bone bonding and (iii) cytocompatibility. In contrast, the sol–gel derived S70C30 glass ceramic consisted of a virtually inert crystalline phase CaSiO3. Moreover, amorphous S70C30 largely transited to CaCO3 with minor hydroxyapatite when immersed in simulated body fluid under standard tissue culture conditions. In conclusion, sol–gel derived Na2O-containing glass ceramics have significant advantages over related Na2O-free materials, having a greatly improved combination of mechanical capability and biological absorbability.
Original languageEnglish
Pages (from-to)4143 - 4153
Number of pages11
JournalActa Biomaterialia
Volume6
Issue number10
DOIs
Publication statusPublished - 2010

Cite this

Chen, Qizhi ; Li, Yuan ; Jin, Liyu ; Quinn, Julian Michael Warner ; Komesaroff, Paul. / A new sol–gel process for producing Na2O-containing bioactive glass ceramics. In: Acta Biomaterialia. 2010 ; Vol. 6, No. 10. pp. 4143 - 4153.
@article{0dd182c45a624541b034d2428a407dad,
title = "A new sol–gel process for producing Na2O-containing bioactive glass ceramics",
abstract = "The sol–gel process of producing SiO2–CaO bioactive glasses is well established, but problems remain with the poor mechanical properties of the amorphous form and the bioinertness of its crystalline counterpart. These properties may be improved by incorporating Na2O into bioactive glasses, which can result in the formation of a hard yet biodegradable crystalline phase from bioactive glasses when sintered. However, production of Na2O-containing bioactive glasses by sol–gel methods has proved to be difficult. This work reports a new sol–gel process for the production of Na2O-containing bioactive glass ceramics, potentially enabling their use as medical implantation materials. Fine powders of 45S5 (a Na2O-containing composition) glass ceramic have for the first time been successfully synthesized using the sol–gel technique in aqueous solution under ambient conditions, with the mean particle size being ∼5 μm. A comparative study of sol–gel derived S70C30 (a Na2O-free composition) and 45S5 glass ceramic materials revealed that the latter possesses a number of features desirable in biomaterials used for bone tissue engineering, including (i) the crystalline phase Na2Ca2Si3O9 that couples good mechanical strength with satisfactory biodegradability, (ii) formation of hydroxyapatite, which may promote good bone bonding and (iii) cytocompatibility. In contrast, the sol–gel derived S70C30 glass ceramic consisted of a virtually inert crystalline phase CaSiO3. Moreover, amorphous S70C30 largely transited to CaCO3 with minor hydroxyapatite when immersed in simulated body fluid under standard tissue culture conditions. In conclusion, sol–gel derived Na2O-containing glass ceramics have significant advantages over related Na2O-free materials, having a greatly improved combination of mechanical capability and biological absorbability.",
author = "Qizhi Chen and Yuan Li and Liyu Jin and Quinn, {Julian Michael Warner} and Paul Komesaroff",
year = "2010",
doi = "10.1016/j.actbio.201.04.022",
language = "English",
volume = "6",
pages = "4143 -- 4153",
journal = "Acta Biomaterialia",
issn = "1742-7061",
publisher = "Elsevier",
number = "10",

}

A new sol–gel process for producing Na2O-containing bioactive glass ceramics. / Chen, Qizhi; Li, Yuan; Jin, Liyu; Quinn, Julian Michael Warner; Komesaroff, Paul.

In: Acta Biomaterialia, Vol. 6, No. 10, 2010, p. 4143 - 4153.

Research output: Contribution to journalArticleResearchpeer-review

TY - JOUR

T1 - A new sol–gel process for producing Na2O-containing bioactive glass ceramics

AU - Chen, Qizhi

AU - Li, Yuan

AU - Jin, Liyu

AU - Quinn, Julian Michael Warner

AU - Komesaroff, Paul

PY - 2010

Y1 - 2010

N2 - The sol–gel process of producing SiO2–CaO bioactive glasses is well established, but problems remain with the poor mechanical properties of the amorphous form and the bioinertness of its crystalline counterpart. These properties may be improved by incorporating Na2O into bioactive glasses, which can result in the formation of a hard yet biodegradable crystalline phase from bioactive glasses when sintered. However, production of Na2O-containing bioactive glasses by sol–gel methods has proved to be difficult. This work reports a new sol–gel process for the production of Na2O-containing bioactive glass ceramics, potentially enabling their use as medical implantation materials. Fine powders of 45S5 (a Na2O-containing composition) glass ceramic have for the first time been successfully synthesized using the sol–gel technique in aqueous solution under ambient conditions, with the mean particle size being ∼5 μm. A comparative study of sol–gel derived S70C30 (a Na2O-free composition) and 45S5 glass ceramic materials revealed that the latter possesses a number of features desirable in biomaterials used for bone tissue engineering, including (i) the crystalline phase Na2Ca2Si3O9 that couples good mechanical strength with satisfactory biodegradability, (ii) formation of hydroxyapatite, which may promote good bone bonding and (iii) cytocompatibility. In contrast, the sol–gel derived S70C30 glass ceramic consisted of a virtually inert crystalline phase CaSiO3. Moreover, amorphous S70C30 largely transited to CaCO3 with minor hydroxyapatite when immersed in simulated body fluid under standard tissue culture conditions. In conclusion, sol–gel derived Na2O-containing glass ceramics have significant advantages over related Na2O-free materials, having a greatly improved combination of mechanical capability and biological absorbability.

AB - The sol–gel process of producing SiO2–CaO bioactive glasses is well established, but problems remain with the poor mechanical properties of the amorphous form and the bioinertness of its crystalline counterpart. These properties may be improved by incorporating Na2O into bioactive glasses, which can result in the formation of a hard yet biodegradable crystalline phase from bioactive glasses when sintered. However, production of Na2O-containing bioactive glasses by sol–gel methods has proved to be difficult. This work reports a new sol–gel process for the production of Na2O-containing bioactive glass ceramics, potentially enabling their use as medical implantation materials. Fine powders of 45S5 (a Na2O-containing composition) glass ceramic have for the first time been successfully synthesized using the sol–gel technique in aqueous solution under ambient conditions, with the mean particle size being ∼5 μm. A comparative study of sol–gel derived S70C30 (a Na2O-free composition) and 45S5 glass ceramic materials revealed that the latter possesses a number of features desirable in biomaterials used for bone tissue engineering, including (i) the crystalline phase Na2Ca2Si3O9 that couples good mechanical strength with satisfactory biodegradability, (ii) formation of hydroxyapatite, which may promote good bone bonding and (iii) cytocompatibility. In contrast, the sol–gel derived S70C30 glass ceramic consisted of a virtually inert crystalline phase CaSiO3. Moreover, amorphous S70C30 largely transited to CaCO3 with minor hydroxyapatite when immersed in simulated body fluid under standard tissue culture conditions. In conclusion, sol–gel derived Na2O-containing glass ceramics have significant advantages over related Na2O-free materials, having a greatly improved combination of mechanical capability and biological absorbability.

UR - http://www.elsevier.com/locate/actabiomat

U2 - 10.1016/j.actbio.201.04.022

DO - 10.1016/j.actbio.201.04.022

M3 - Article

VL - 6

SP - 4143

EP - 4153

JO - Acta Biomaterialia

JF - Acta Biomaterialia

SN - 1742-7061

IS - 10

ER -