Abstract
CCR5 has been associated with adaptive immune responses, because of its expression on effector and memory T cells, and dentric cells. In this issue of the European Journal of Immunology, Whittall et al. identify CCR5 as a receptor that binds bacterial heat shock protein 70 (HSP70). Thus HSP70 may stimulate responses by CCR5+ T cells or dendritic cells, particularly at epithelial surfaces. These findings imply a role for CCR5 in innate immunity, in addition to its more established role as a chemoattractant receptor for adaptive immune responses.
Original language | English |
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Pages (from-to) | 2293-2295 |
Number of pages | 3 |
Journal | European Journal of Immunology |
Volume | 36 |
Issue number | 9 |
DOIs |
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Publication status | Published - 1 Sep 2006 |
Externally published | Yes |
Keywords
- CCR5
- HSP70
- Infection
- Innate immunity