A new role for CCR5 in innate immunity - Binding to bacterial heat shock protein 70

Charles R. Mackay, Federica Sallusto

Research output: Contribution to journalComment / DebateOtherpeer-review

5 Citations (Scopus)

Abstract

CCR5 has been associated with adaptive immune responses, because of its expression on effector and memory T cells, and dentric cells. In this issue of the European Journal of Immunology, Whittall et al. identify CCR5 as a receptor that binds bacterial heat shock protein 70 (HSP70). Thus HSP70 may stimulate responses by CCR5+ T cells or dendritic cells, particularly at epithelial surfaces. These findings imply a role for CCR5 in innate immunity, in addition to its more established role as a chemoattractant receptor for adaptive immune responses.

Original languageEnglish
Pages (from-to)2293-2295
Number of pages3
JournalEuropean Journal of Immunology
Volume36
Issue number9
DOIs
Publication statusPublished - 1 Sep 2006
Externally publishedYes

Keywords

  • CCR5
  • HSP70
  • Infection
  • Innate immunity

Cite this