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A new method for the fast synthesis of diverse 4-aryl-6-cycloamino-1,3,5-triazin-2-amines was developed. The synthesis is performed under microwave irradiation in a one-pot manner from cyanoguanidine, aromatic aldehydes, and cyclic amines. Their three-component reaction in the presence of hydrochloric acid produced dihydrotriazines, which were then converted (without isolation) into the targeted compounds via aromatic dehydrogenation in the presence of alkali. The reaction tolerated various aromatic aldehydes (including heterocyclic) and cyclic amines. Crystal structures of two representative 4-aryl-6-morpholino-1,3,5-triazin-2-amines were established by X-ray crystallography. The results of preliminary biological screening identified potent antileukemic activity for 6-[3,4-dihydroisoquinolin-2(1 H)-yl]-4-phenyl-1,3,5-triazin-2-amine.
|Number of pages||12|
|Publication status||Published - 20 Jul 2021|
- antiproliferative activity
- dehydrogenative aromatization
- microwave-assisted synthesis
- multicomponent reactions
- 1 Active
QSAR-guided, molecular diversity oriented synthesis and evaluation of 1,3,5-triazine derivatives as potent and selective anticancer agents
Dolzhenko, A. V., Tiekink, E. R. T., Chuah, A., Othman, I. & Lim, S. W.
1/11/20 → 31/10/23