A new, one-pot, multicomponent synthesis of 5-aza-9-deaza-adenines under microwave irradiation

Felicia Phei Lin Lim, Giuseppe Luna, Anton V Dolzhenko

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A new, practical, three-component method for the synthesis of 5-aza-9-deaza-adenines is developed. Aminopyrazoles react in a one-pot fashion with triethyl orthoformate and cyanamide under microwave irradiation affording 5-aza-9-deaza-adenines in good yields and high purity. The main advantages of this method are the operational simplicity, accessibility, and high efficiency.
Original languageEnglish
Pages (from-to)5159-5163
Number of pages5
JournalTetrahedron Letters
Issue number37
Publication statusPublished - 2014

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