A new, practical, three-component method for the synthesis of 5-aza-9-deaza-adenines is developed. Aminopyrazoles react in a one-pot fashion with triethyl orthoformate and cyanamide under microwave irradiation affording 5-aza-9-deaza-adenines in good yields and high purity. The main advantages of this method are the operational simplicity, accessibility, and high efficiency.
Lim, F. P. L., Luna, G., & Dolzhenko, A. V. (2014). A new, one-pot, multicomponent synthesis of 5-aza-9-deaza-adenines under microwave irradiation. Tetrahedron Letters, 55(37), 5159 - 5163. https://doi.org/10.1016/j.tetlet.2014.07.105