A new neonatal cortical and subcortical brain atlas: The Melbourne Children's Regional Infant Brain (M-CRIB) atlas

Bonnie Alexander, Andrea L. Murray, Wai Yen Loh, Lillian G. Matthews, Chris Adamson, Richard Beare, Jian Chen, Claire E. Kelly, Sandra Rees, Simon K. Warfield, Peter J. Anderson, Lex W. Doyle, Alicia J. Spittle, Jeanie L.Y. Cheong, Marc L. Seal, Deanne K. Thompson

Research output: Contribution to journalArticleResearchpeer-review

Abstract

Investigating neonatal brain structure and function can offer valuable insights into behaviour and cognition in healthy and clinical populations; both at term age, and longitudinally in comparison with later time points. Parcellated brain atlases for adult populations are readily available, however warping infant data to adult template space is not ideal due to morphological and tissue differences between these groups. Several parcellated neonatal atlases have been developed, although there remains strong demand for manually parcellated ground truth data with detailed cortical definition. Additionally, compatibility with existing adult atlases is favourable for use in longitudinal investigations. We aimed to address these needs by replicating the widely-used Desikan-Killiany (2006) adult cortical atlas in neonates. We also aimed to extend brain coverage by complementing this cortical scheme with basal ganglia, thalamus, cerebellum and other subcortical segmentations. Thus, we have manually parcellated these areas volumetrically using high-resolution neonatal T2-weighted MRI scans, and initial automated and manually edited tissue classification, providing 100 regions in all. Linear and nonlinear T2-weighted structural templates were also generated. In this paper we provide manual parcellation protocols, and present the parcellated probability maps and structural templates together as the Melbourne Children's Regional Infant Brain (M-CRIB) atlas.

Original languageEnglish
Pages (from-to)841-851
Number of pages11
JournalNeuroImage
Volume147
DOIs
Publication statusPublished - 15 Feb 2017

Keywords

  • Ground truth
  • Infant
  • Manual parcellation
  • T2-weighted MRI
  • Template

Cite this

Alexander, Bonnie ; Murray, Andrea L. ; Loh, Wai Yen ; Matthews, Lillian G. ; Adamson, Chris ; Beare, Richard ; Chen, Jian ; Kelly, Claire E. ; Rees, Sandra ; Warfield, Simon K. ; Anderson, Peter J. ; Doyle, Lex W. ; Spittle, Alicia J. ; Cheong, Jeanie L.Y. ; Seal, Marc L. ; Thompson, Deanne K. / A new neonatal cortical and subcortical brain atlas : The Melbourne Children's Regional Infant Brain (M-CRIB) atlas. In: NeuroImage. 2017 ; Vol. 147. pp. 841-851.
@article{32694c1091744f47aa4c5c32d27cd073,
title = "A new neonatal cortical and subcortical brain atlas: The Melbourne Children's Regional Infant Brain (M-CRIB) atlas",
abstract = "Investigating neonatal brain structure and function can offer valuable insights into behaviour and cognition in healthy and clinical populations; both at term age, and longitudinally in comparison with later time points. Parcellated brain atlases for adult populations are readily available, however warping infant data to adult template space is not ideal due to morphological and tissue differences between these groups. Several parcellated neonatal atlases have been developed, although there remains strong demand for manually parcellated ground truth data with detailed cortical definition. Additionally, compatibility with existing adult atlases is favourable for use in longitudinal investigations. We aimed to address these needs by replicating the widely-used Desikan-Killiany (2006) adult cortical atlas in neonates. We also aimed to extend brain coverage by complementing this cortical scheme with basal ganglia, thalamus, cerebellum and other subcortical segmentations. Thus, we have manually parcellated these areas volumetrically using high-resolution neonatal T2-weighted MRI scans, and initial automated and manually edited tissue classification, providing 100 regions in all. Linear and nonlinear T2-weighted structural templates were also generated. In this paper we provide manual parcellation protocols, and present the parcellated probability maps and structural templates together as the Melbourne Children's Regional Infant Brain (M-CRIB) atlas.",
keywords = "Ground truth, Infant, Manual parcellation, T2-weighted MRI, Template",
author = "Bonnie Alexander and Murray, {Andrea L.} and Loh, {Wai Yen} and Matthews, {Lillian G.} and Chris Adamson and Richard Beare and Jian Chen and Kelly, {Claire E.} and Sandra Rees and Warfield, {Simon K.} and Anderson, {Peter J.} and Doyle, {Lex W.} and Spittle, {Alicia J.} and Cheong, {Jeanie L.Y.} and Seal, {Marc L.} and Thompson, {Deanne K.}",
year = "2017",
month = "2",
day = "15",
doi = "10.1016/j.neuroimage.2016.09.068",
language = "English",
volume = "147",
pages = "841--851",
journal = "NeuroImage",
issn = "1053-8119",
publisher = "Elsevier",

}

Alexander, B, Murray, AL, Loh, WY, Matthews, LG, Adamson, C, Beare, R, Chen, J, Kelly, CE, Rees, S, Warfield, SK, Anderson, PJ, Doyle, LW, Spittle, AJ, Cheong, JLY, Seal, ML & Thompson, DK 2017, 'A new neonatal cortical and subcortical brain atlas: The Melbourne Children's Regional Infant Brain (M-CRIB) atlas' NeuroImage, vol. 147, pp. 841-851. https://doi.org/10.1016/j.neuroimage.2016.09.068

A new neonatal cortical and subcortical brain atlas : The Melbourne Children's Regional Infant Brain (M-CRIB) atlas. / Alexander, Bonnie; Murray, Andrea L.; Loh, Wai Yen; Matthews, Lillian G.; Adamson, Chris; Beare, Richard; Chen, Jian; Kelly, Claire E.; Rees, Sandra; Warfield, Simon K.; Anderson, Peter J.; Doyle, Lex W.; Spittle, Alicia J.; Cheong, Jeanie L.Y.; Seal, Marc L.; Thompson, Deanne K.

In: NeuroImage, Vol. 147, 15.02.2017, p. 841-851.

Research output: Contribution to journalArticleResearchpeer-review

TY - JOUR

T1 - A new neonatal cortical and subcortical brain atlas

T2 - The Melbourne Children's Regional Infant Brain (M-CRIB) atlas

AU - Alexander, Bonnie

AU - Murray, Andrea L.

AU - Loh, Wai Yen

AU - Matthews, Lillian G.

AU - Adamson, Chris

AU - Beare, Richard

AU - Chen, Jian

AU - Kelly, Claire E.

AU - Rees, Sandra

AU - Warfield, Simon K.

AU - Anderson, Peter J.

AU - Doyle, Lex W.

AU - Spittle, Alicia J.

AU - Cheong, Jeanie L.Y.

AU - Seal, Marc L.

AU - Thompson, Deanne K.

PY - 2017/2/15

Y1 - 2017/2/15

N2 - Investigating neonatal brain structure and function can offer valuable insights into behaviour and cognition in healthy and clinical populations; both at term age, and longitudinally in comparison with later time points. Parcellated brain atlases for adult populations are readily available, however warping infant data to adult template space is not ideal due to morphological and tissue differences between these groups. Several parcellated neonatal atlases have been developed, although there remains strong demand for manually parcellated ground truth data with detailed cortical definition. Additionally, compatibility with existing adult atlases is favourable for use in longitudinal investigations. We aimed to address these needs by replicating the widely-used Desikan-Killiany (2006) adult cortical atlas in neonates. We also aimed to extend brain coverage by complementing this cortical scheme with basal ganglia, thalamus, cerebellum and other subcortical segmentations. Thus, we have manually parcellated these areas volumetrically using high-resolution neonatal T2-weighted MRI scans, and initial automated and manually edited tissue classification, providing 100 regions in all. Linear and nonlinear T2-weighted structural templates were also generated. In this paper we provide manual parcellation protocols, and present the parcellated probability maps and structural templates together as the Melbourne Children's Regional Infant Brain (M-CRIB) atlas.

AB - Investigating neonatal brain structure and function can offer valuable insights into behaviour and cognition in healthy and clinical populations; both at term age, and longitudinally in comparison with later time points. Parcellated brain atlases for adult populations are readily available, however warping infant data to adult template space is not ideal due to morphological and tissue differences between these groups. Several parcellated neonatal atlases have been developed, although there remains strong demand for manually parcellated ground truth data with detailed cortical definition. Additionally, compatibility with existing adult atlases is favourable for use in longitudinal investigations. We aimed to address these needs by replicating the widely-used Desikan-Killiany (2006) adult cortical atlas in neonates. We also aimed to extend brain coverage by complementing this cortical scheme with basal ganglia, thalamus, cerebellum and other subcortical segmentations. Thus, we have manually parcellated these areas volumetrically using high-resolution neonatal T2-weighted MRI scans, and initial automated and manually edited tissue classification, providing 100 regions in all. Linear and nonlinear T2-weighted structural templates were also generated. In this paper we provide manual parcellation protocols, and present the parcellated probability maps and structural templates together as the Melbourne Children's Regional Infant Brain (M-CRIB) atlas.

KW - Ground truth

KW - Infant

KW - Manual parcellation

KW - T2-weighted MRI

KW - Template

UR - http://www.scopus.com/inward/record.url?scp=85006154530&partnerID=8YFLogxK

U2 - 10.1016/j.neuroimage.2016.09.068

DO - 10.1016/j.neuroimage.2016.09.068

M3 - Article

VL - 147

SP - 841

EP - 851

JO - NeuroImage

JF - NeuroImage

SN - 1053-8119

ER -