A new fused transcript in philadelphia chromosome positive acute lymphocytic leukaemia

E. Fainstein, C. Marcelle, A. Rosner, E. Canaani, R. P. Gale, O. Dreazen, S. D. Smith, C. M. Croce

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Abstract

The leukaemic cells of more than 90% of chronic myelogenous leukaemia (CML) patients and of 10% of acute lymphocytic leukaemia (ALL) patients carry the t(9:22) (q34:qll) translocation which generates the Philadelphia chromosome (Ph1). In CML the abl gene is translocated from chromosome 9 to the centre of the bcr gene on chromosome 22 and this results in production of chimaeric bcr-abl RNA translated into a protein of relative molecular mass (Mr) 210,000 (210K). Our data indicate that in ALL abl is translocated into the 5' region of the bcr gene. The consequence of this is the expression of a fused transcript in which the first exon of bcr is linked to the second abl exon. This transcript encodes a 190K protein kinase.

Original languageEnglish
Pages (from-to)386-388
Number of pages3
JournalNature
Volume330
Issue number6146
DOIs
Publication statusPublished - 1987
Externally publishedYes

Cite this

Fainstein, E., Marcelle, C., Rosner, A., Canaani, E., Gale, R. P., Dreazen, O., Smith, S. D., & Croce, C. M. (1987). A new fused transcript in philadelphia chromosome positive acute lymphocytic leukaemia. Nature, 330(6146), 386-388. https://doi.org/10.1038/330386a0