A new double-responsive block copolymer synthesized via RAFT polymerization: Poly(N-isopropylacrylamide)-block-poly(acrylic acid)

Christine M. Schilli; Mingfu Zhang; Ezio Rizzardo; San H. Thang; Y. K. Chong; Katarina Edwards; Göran Karlsson; Axel H E Müller

doi:10.1021/ma035838w

A new double-responsive block copolymer synthesized via RAFT polymerization: Poly(N-isopropylacrylamide)-block-poly(acrylic acid)

Christine M. Schilli, Mingfu Zhang, Ezio Rizzardo, San H. Thang, Y. K. Chong, Katarina Edwards, Göran Karlsson, Axel H E Müller

Research output: Contribution to journal › Article › Research › peer-review

545 Citations (Scopus)

Abstract

Poly(N-isopropylacrylamide)-block-poly(acrylic acid), PNIPAAm-b-PAA, with low polydispersity was prepared by reversible addition-fragmentation chain transfer (RAFT) polymerization in methanol. The block copolymers respond to both temperature and pH stimuli. The behavior of the double-responsive block copolymers in solution was investigated by dynamic light scattering, temperature-sweep NMR, cryogenic transmission electron microscopy, and IR spectroscopy. The block copolymers form micelles in aqueous solutions in dependence of pH and temperature. Cloud point measurements indicated the formation of larger aggregates at pH 4.5 and temperatures above the lower critical solution temperature (LCST) of PNIPAAm. The solution behavior is strongly influenced by hydrogen bonding interactions between the NIPAAm and acrylic acid blocks.

Original language	English
Pages (from-to)	7861-7866
Number of pages	6
Journal	Macromolecules
Volume	37
Issue number	21
DOIs	https://doi.org/10.1021/ma035838w
Publication status	Published - 19 Oct 2004
Externally published	Yes

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title = "A new double-responsive block copolymer synthesized via RAFT polymerization: Poly(N-isopropylacrylamide)-block-poly(acrylic acid)",

abstract = "Poly(N-isopropylacrylamide)-block-poly(acrylic acid), PNIPAAm-b-PAA, with low polydispersity was prepared by reversible addition-fragmentation chain transfer (RAFT) polymerization in methanol. The block copolymers respond to both temperature and pH stimuli. The behavior of the double-responsive block copolymers in solution was investigated by dynamic light scattering, temperature-sweep NMR, cryogenic transmission electron microscopy, and IR spectroscopy. The block copolymers form micelles in aqueous solutions in dependence of pH and temperature. Cloud point measurements indicated the formation of larger aggregates at pH 4.5 and temperatures above the lower critical solution temperature (LCST) of PNIPAAm. The solution behavior is strongly influenced by hydrogen bonding interactions between the NIPAAm and acrylic acid blocks.",

author = "Schilli, {Christine M.} and Mingfu Zhang and Ezio Rizzardo and Thang, {San H.} and Chong, {Y. K.} and Katarina Edwards and G{\"o}ran Karlsson and M{\"u}ller, {Axel H E}",

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doi = "10.1021/ma035838w",

language = "English",

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T1 - A new double-responsive block copolymer synthesized via RAFT polymerization

T2 - Poly(N-isopropylacrylamide)-block-poly(acrylic acid)

AU - Schilli, Christine M.

AU - Zhang, Mingfu

AU - Rizzardo, Ezio

AU - Thang, San H.

AU - Chong, Y. K.

AU - Edwards, Katarina

AU - Karlsson, Göran

AU - Müller, Axel H E

PY - 2004/10/19

Y1 - 2004/10/19

N2 - Poly(N-isopropylacrylamide)-block-poly(acrylic acid), PNIPAAm-b-PAA, with low polydispersity was prepared by reversible addition-fragmentation chain transfer (RAFT) polymerization in methanol. The block copolymers respond to both temperature and pH stimuli. The behavior of the double-responsive block copolymers in solution was investigated by dynamic light scattering, temperature-sweep NMR, cryogenic transmission electron microscopy, and IR spectroscopy. The block copolymers form micelles in aqueous solutions in dependence of pH and temperature. Cloud point measurements indicated the formation of larger aggregates at pH 4.5 and temperatures above the lower critical solution temperature (LCST) of PNIPAAm. The solution behavior is strongly influenced by hydrogen bonding interactions between the NIPAAm and acrylic acid blocks.

AB - Poly(N-isopropylacrylamide)-block-poly(acrylic acid), PNIPAAm-b-PAA, with low polydispersity was prepared by reversible addition-fragmentation chain transfer (RAFT) polymerization in methanol. The block copolymers respond to both temperature and pH stimuli. The behavior of the double-responsive block copolymers in solution was investigated by dynamic light scattering, temperature-sweep NMR, cryogenic transmission electron microscopy, and IR spectroscopy. The block copolymers form micelles in aqueous solutions in dependence of pH and temperature. Cloud point measurements indicated the formation of larger aggregates at pH 4.5 and temperatures above the lower critical solution temperature (LCST) of PNIPAAm. The solution behavior is strongly influenced by hydrogen bonding interactions between the NIPAAm and acrylic acid blocks.

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JO - Macromolecules

JF - Macromolecules

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ER -

A new double-responsive block copolymer synthesized via RAFT polymerization: Poly(N-isopropylacrylamide)-block-poly(acrylic acid)

Abstract

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