A new design for high stability pressure-controlled ventilation for small animal lung imaging

Research output: Contribution to journalArticleResearchpeer-review

Abstract

We have developed a custom-designed ventilator to deliver a stable pressure to the lungs of small animals for use in imaging experiments. Our ventilator was designed with independent pressure vessels to separately control the Peak Inspiratory Pressure (PIP) and Positive End Expiratory Pressure (PEEP) to minimise pressure fluctuations during the ventilation process. The ventilator was computer controlled through a LabVIEW interface, enabling experimental manipulations to be performed remotely whilst simultaneously imaging the lungs in situ. Mechanical ventilation was successfully performed on newborn rabbit pups to assess the most effective ventilation strategies for aerating the lungs at birth. Highly stable pressures enabled reliable respiratory gated acquisition of projection radiographs and a stable prolonged (15 minute) breath-hold for high-resolution computed tomography of deceased rabbit pups at different lung volumes.
Original languageEnglish
Pages (from-to)1 - 12
Number of pages12
JournalJournal of Instrumentation
Volume5
Issue number2
DOIs
Publication statusPublished - 2010

Cite this

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title = "A new design for high stability pressure-controlled ventilation for small animal lung imaging",
abstract = "We have developed a custom-designed ventilator to deliver a stable pressure to the lungs of small animals for use in imaging experiments. Our ventilator was designed with independent pressure vessels to separately control the Peak Inspiratory Pressure (PIP) and Positive End Expiratory Pressure (PEEP) to minimise pressure fluctuations during the ventilation process. The ventilator was computer controlled through a LabVIEW interface, enabling experimental manipulations to be performed remotely whilst simultaneously imaging the lungs in situ. Mechanical ventilation was successfully performed on newborn rabbit pups to assess the most effective ventilation strategies for aerating the lungs at birth. Highly stable pressures enabled reliable respiratory gated acquisition of projection radiographs and a stable prolonged (15 minute) breath-hold for high-resolution computed tomography of deceased rabbit pups at different lung volumes.",
author = "Marcus Kitchen and Anowarul Habib and Andreas Fouras and Stephen Dubsky and Robert Lewis and Megan Wallace and Stuart Hooper",
year = "2010",
doi = "10.1088/1748-0221/5/02/T02002",
language = "English",
volume = "5",
pages = "1 -- 12",
journal = "Journal of Instrumentation",
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publisher = "IOP Publishing",
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}

A new design for high stability pressure-controlled ventilation for small animal lung imaging. / Kitchen, Marcus; Habib, Anowarul; Fouras, Andreas; Dubsky, Stephen; Lewis, Robert; Wallace, Megan; Hooper, Stuart.

In: Journal of Instrumentation, Vol. 5, No. 2, 2010, p. 1 - 12.

Research output: Contribution to journalArticleResearchpeer-review

TY - JOUR

T1 - A new design for high stability pressure-controlled ventilation for small animal lung imaging

AU - Kitchen, Marcus

AU - Habib, Anowarul

AU - Fouras, Andreas

AU - Dubsky, Stephen

AU - Lewis, Robert

AU - Wallace, Megan

AU - Hooper, Stuart

PY - 2010

Y1 - 2010

N2 - We have developed a custom-designed ventilator to deliver a stable pressure to the lungs of small animals for use in imaging experiments. Our ventilator was designed with independent pressure vessels to separately control the Peak Inspiratory Pressure (PIP) and Positive End Expiratory Pressure (PEEP) to minimise pressure fluctuations during the ventilation process. The ventilator was computer controlled through a LabVIEW interface, enabling experimental manipulations to be performed remotely whilst simultaneously imaging the lungs in situ. Mechanical ventilation was successfully performed on newborn rabbit pups to assess the most effective ventilation strategies for aerating the lungs at birth. Highly stable pressures enabled reliable respiratory gated acquisition of projection radiographs and a stable prolonged (15 minute) breath-hold for high-resolution computed tomography of deceased rabbit pups at different lung volumes.

AB - We have developed a custom-designed ventilator to deliver a stable pressure to the lungs of small animals for use in imaging experiments. Our ventilator was designed with independent pressure vessels to separately control the Peak Inspiratory Pressure (PIP) and Positive End Expiratory Pressure (PEEP) to minimise pressure fluctuations during the ventilation process. The ventilator was computer controlled through a LabVIEW interface, enabling experimental manipulations to be performed remotely whilst simultaneously imaging the lungs in situ. Mechanical ventilation was successfully performed on newborn rabbit pups to assess the most effective ventilation strategies for aerating the lungs at birth. Highly stable pressures enabled reliable respiratory gated acquisition of projection radiographs and a stable prolonged (15 minute) breath-hold for high-resolution computed tomography of deceased rabbit pups at different lung volumes.

UR - http://iopscience.iop.org/1748-0221/5/02/T02002/pdf/1748-0221_5_02_T02002.pdf

U2 - 10.1088/1748-0221/5/02/T02002

DO - 10.1088/1748-0221/5/02/T02002

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SP - 1

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JO - Journal of Instrumentation

JF - Journal of Instrumentation

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