Abstract
Non-traditional amphiphiles: Conferring aqueous solubility on membrane proteins generally requires the use of a detergent or other amphiphilic agent. A new class of amphiphiles was synthesized, based on steroidal lipophilic groups, and evaluated with several membrane proteins. The results show that the new amphiphile, "glyco-diosgenin" (GDN; see figure), confers enhanced stability to a variety of membrane proteins in solution relative to popular conventional detergents, such as dodecylmaltoside (DDM).
Original language | English |
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Pages (from-to) | 9485-9490 |
Number of pages | 6 |
Journal | Chemistry - A European Journal |
Volume | 18 |
Issue number | 31 |
DOIs | |
Publication status | Published - 27 Jul 2012 |
Externally published | Yes |
Keywords
- amphiphiles
- membrane proteins
- molecular design
- solubilization
- stabilization