A new asymmetric synthesis of (+)-grandisol via a kinetic resolution

David P G Hamon; Kellie L. Tuck

doi:10.1016/S0040-4039(99)01605-6

A new asymmetric synthesis of (+)-grandisol via a kinetic resolution

David P G Hamon, Kellie L. Tuck

Research output: Contribution to journal › Article › Research › peer-review

10 Citations (Scopus)

Abstract

A novel approach to the asymmetric synthesis of (+)-grandisol involves the use of catalytic kinetic resolution of a primary allylic alcohol. The allylic alcohol is prepared in 4 steps from simple achiral materials and the resolved alcohol (95%e.e.) is reduced in 2 steps to the corresponding methyl alkene. This alkene is converted to (+)-grandisol (95%e.e.).

Original language	English
Pages (from-to)	7569-7572
Number of pages	4
Journal	Tetrahedron Letters
Volume	40
Issue number	42
DOIs	https://doi.org/10.1016/S0040-4039(99)01605-6
Publication status	Published - 15 Oct 1999
Externally published	Yes

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title = "A new asymmetric synthesis of (+)-grandisol via a kinetic resolution",

abstract = "A novel approach to the asymmetric synthesis of (+)-grandisol involves the use of catalytic kinetic resolution of a primary allylic alcohol. The allylic alcohol is prepared in 4 steps from simple achiral materials and the resolved alcohol (95%e.e.) is reduced in 2 steps to the corresponding methyl alkene. This alkene is converted to (+)-grandisol (95%e.e.).",

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AU - Tuck, Kellie L.

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N2 - A novel approach to the asymmetric synthesis of (+)-grandisol involves the use of catalytic kinetic resolution of a primary allylic alcohol. The allylic alcohol is prepared in 4 steps from simple achiral materials and the resolved alcohol (95%e.e.) is reduced in 2 steps to the corresponding methyl alkene. This alkene is converted to (+)-grandisol (95%e.e.).

AB - A novel approach to the asymmetric synthesis of (+)-grandisol involves the use of catalytic kinetic resolution of a primary allylic alcohol. The allylic alcohol is prepared in 4 steps from simple achiral materials and the resolved alcohol (95%e.e.) is reduced in 2 steps to the corresponding methyl alkene. This alkene is converted to (+)-grandisol (95%e.e.).

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U2 - 10.1016/S0040-4039(99)01605-6

DO - 10.1016/S0040-4039(99)01605-6

M3 - Article

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EP - 7572

JO - Tetrahedron Letters

JF - Tetrahedron Letters

SN - 0040-4039

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ER -

A new asymmetric synthesis of (+)-grandisol via a kinetic resolution

Abstract

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