A new asymmetric synthesis of (+)-grandisol via a kinetic resolution

David P G Hamon, Kellie L. Tuck

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Abstract

A novel approach to the asymmetric synthesis of (+)-grandisol involves the use of catalytic kinetic resolution of a primary allylic alcohol. The allylic alcohol is prepared in 4 steps from simple achiral materials and the resolved alcohol (95%e.e.) is reduced in 2 steps to the corresponding methyl alkene. This alkene is converted to (+)-grandisol (95%e.e.).

Original languageEnglish
Pages (from-to)7569-7572
Number of pages4
JournalTetrahedron Letters
Volume40
Issue number42
DOIs
Publication statusPublished - 15 Oct 1999
Externally publishedYes

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