A new approach to highly substituted cyclopentanoids from a concise formal synthesis of (+)-roseophilin

Daniel Jarrah Kerr; Bernard Luke Flynn

doi:10.1021/ol300332b

A new approach to highly substituted cyclopentanoids from a concise formal synthesis of (+)-roseophilin

Daniel Jarrah Kerr, Bernard Luke Flynn

Medicinal Chemistry

Research output: Contribution to journal › Article › Research › peer-review

24 Citations (Scopus)

Abstract

A convergent reaction sequence involving a reductive coupling and a chiral Bronsted acid catalyzed Nazarov reaction is utilized in a concise formal synthesis of (+)-roseophilin (11 steps via longest linear sequence, 10.2 yield, 95 ee).

Original language	English
Pages (from-to)	1740 - 1743
Number of pages	4
Journal	Organic Letters
Volume	14
Issue number	7
DOIs	https://doi.org/10.1021/ol300332b
Publication status	Published - 2012

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10.1021/ol300332b

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Cite this

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title = "A new approach to highly substituted cyclopentanoids from a concise formal synthesis of (+)-roseophilin",

abstract = "A convergent reaction sequence involving a reductive coupling and a chiral Bronsted acid catalyzed Nazarov reaction is utilized in a concise formal synthesis of (+)-roseophilin (11 steps via longest linear sequence, 10.2 yield, 95 ee).",

author = "Kerr, {Daniel Jarrah} and Flynn, {Bernard Luke}",

year = "2012",

doi = "10.1021/ol300332b",

language = "English",

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pages = "1740 -- 1743",

journal = "Organic Letters",

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AU - Flynn, Bernard Luke

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AB - A convergent reaction sequence involving a reductive coupling and a chiral Bronsted acid catalyzed Nazarov reaction is utilized in a concise formal synthesis of (+)-roseophilin (11 steps via longest linear sequence, 10.2 yield, 95 ee).

UR - http://pubs.acs.org/journal/orlef7

U2 - 10.1021/ol300332b

DO - 10.1021/ol300332b

M3 - Article

VL - 14

SP - 1740

EP - 1743

JO - Organic Letters

JF - Organic Letters

SN - 1523-7060

IS - 7

ER -