A near infra-red study of blood oxygenation changes resulting from high and low frequency repetitive transcranial magnetic stimulation

Ting T. Cao; Richard H. Thomson; Neil W. Bailey; Nigel C. Rogasch; Rebecca A. Segrave; Jerome J. Maller; Zafiris J. Daskalakis; Paul B. Fitzgerald

doi:10.1016/j.brs.2015.01.171

A near infra-red study of blood oxygenation changes resulting from high and low frequency repetitive transcranial magnetic stimulation

Ting T. Cao, Richard H. Thomson, Neil W. Bailey, Nigel C. Rogasch, Rebecca A. Segrave, Jerome J. Maller, Zafiris J. Daskalakis, Paul B. Fitzgerald

Department of Psychiatry (STM)

Research output: Contribution to conference › Abstract › peer-review

Abstract

High and low frequency repetitive transcranial magnetic stimulation (rTMS) are both used to treat major depressive disorder (MDD). However, the physiological mechanisms underlying the therapeutic benefit and the effect of the stimulation frequency are unclear.

Twelve healthy participants received 1Hz, 2Hz and 5Hz active rTMS. Twenty 5 second trains were delivered at left dorsolateral prefrontal cortex at 110% of resting motor threshold with a 25 second inter-train interval.

Blood oxygenation (HbO) was significantly reduced following the 1Hz trains compared to the HbO increases observed in both the 2Hz and 5Hz conditions. There was no significant inter-hemispheric difference in response.

These results suggest that short trains of high and low frequency rTMS delivered to prefrontal cortex evoke a differential HbO response and provide additional evidence that high frequency trains result in increased neural activity. The findings may provide further explanation for the improved symptoms observed in MDD patients treated with high frequency rTMS.

Original language	English
Pages	364
Number of pages	1
DOIs	https://doi.org/10.1016/j.brs.2015.01.171
Publication status	Published - 2015
Event	International Brain Stimulation Conference 2015 - Singapore Expo Convention and Exhibition Centre, Singapore, Singapore Duration: 2 Mar 2015 → 4 Mar 2015 Conference number: 1st http://www.globaleventslist.elsevier.com/events/2015/03/1st-international-brain-stimulation-conference/

Conference

Conference	International Brain Stimulation Conference 2015
Country/Territory	Singapore
City	Singapore
Period	2/03/15 → 4/03/15
Internet address	http://www.globaleventslist.elsevier.com/events/2015/03/1st-international-brain-stimulation-conference/

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Cao, T. T., Thomson, R. H., Bailey, N. W., Rogasch, N. C., Segrave, R. A., Maller, J. J., Daskalakis, Z. J., & Fitzgerald, P. B. (2015). A near infra-red study of blood oxygenation changes resulting from high and low frequency repetitive transcranial magnetic stimulation. 364. Abstract from International Brain Stimulation Conference 2015, Singapore, Singapore. https://doi.org/10.1016/j.brs.2015.01.171

@conference{3551856ab168499db0f64bdd27e38527,

title = "A near infra-red study of blood oxygenation changes resulting from high and low frequency repetitive transcranial magnetic stimulation",

abstract = "High and low frequency repetitive transcranial magnetic stimulation (rTMS) are both used to treat major depressive disorder (MDD). However, the physiological mechanisms underlying the therapeutic benefit and the effect of the stimulation frequency are unclear.Twelve healthy participants received 1Hz, 2Hz and 5Hz active rTMS. Twenty 5 second trains were delivered at left dorsolateral prefrontal cortex at 110% of resting motor threshold with a 25 second inter-train interval.Blood oxygenation (HbO) was significantly reduced following the 1Hz trains compared to the HbO increases observed in both the 2Hz and 5Hz conditions. There was no significant inter-hemispheric difference in response.These results suggest that short trains of high and low frequency rTMS delivered to prefrontal cortex evoke a differential HbO response and provide additional evidence that high frequency trains result in increased neural activity. The findings may provide further explanation for the improved symptoms observed in MDD patients treated with high frequency rTMS.",

author = "Cao, {Ting T.} and Thomson, {Richard H.} and Bailey, {Neil W.} and Rogasch, {Nigel C.} and Segrave, {Rebecca A.} and Maller, {Jerome J.} and Daskalakis, {Zafiris J.} and Fitzgerald, {Paul B.}",

year = "2015",

doi = "10.1016/j.brs.2015.01.171",

language = "English",

pages = "364",

note = "International Brain Stimulation Conference 2015 ; Conference date: 02-03-2015 Through 04-03-2015",

url = "http://www.globaleventslist.elsevier.com/events/2015/03/1st-international-brain-stimulation-conference/",

}

Cao, TT, Thomson, RH, Bailey, NW , Rogasch, NC, Segrave, RA, Maller, JJ, Daskalakis, ZJ & Fitzgerald, PB 2015, 'A near infra-red study of blood oxygenation changes resulting from high and low frequency repetitive transcranial magnetic stimulation', International Brain Stimulation Conference 2015, Singapore, Singapore, 2/03/15 - 4/03/15 pp. 364. https://doi.org/10.1016/j.brs.2015.01.171

TY - CONF

T1 - A near infra-red study of blood oxygenation changes resulting from high and low frequency repetitive transcranial magnetic stimulation

AU - Cao, Ting T.

AU - Thomson, Richard H.

AU - Bailey, Neil W.

AU - Rogasch, Nigel C.

AU - Segrave, Rebecca A.

AU - Maller, Jerome J.

AU - Daskalakis, Zafiris J.

AU - Fitzgerald, Paul B.

N1 - Conference code: 1st

PY - 2015

Y1 - 2015

N2 - High and low frequency repetitive transcranial magnetic stimulation (rTMS) are both used to treat major depressive disorder (MDD). However, the physiological mechanisms underlying the therapeutic benefit and the effect of the stimulation frequency are unclear.Twelve healthy participants received 1Hz, 2Hz and 5Hz active rTMS. Twenty 5 second trains were delivered at left dorsolateral prefrontal cortex at 110% of resting motor threshold with a 25 second inter-train interval.Blood oxygenation (HbO) was significantly reduced following the 1Hz trains compared to the HbO increases observed in both the 2Hz and 5Hz conditions. There was no significant inter-hemispheric difference in response.These results suggest that short trains of high and low frequency rTMS delivered to prefrontal cortex evoke a differential HbO response and provide additional evidence that high frequency trains result in increased neural activity. The findings may provide further explanation for the improved symptoms observed in MDD patients treated with high frequency rTMS.

AB - High and low frequency repetitive transcranial magnetic stimulation (rTMS) are both used to treat major depressive disorder (MDD). However, the physiological mechanisms underlying the therapeutic benefit and the effect of the stimulation frequency are unclear.Twelve healthy participants received 1Hz, 2Hz and 5Hz active rTMS. Twenty 5 second trains were delivered at left dorsolateral prefrontal cortex at 110% of resting motor threshold with a 25 second inter-train interval.Blood oxygenation (HbO) was significantly reduced following the 1Hz trains compared to the HbO increases observed in both the 2Hz and 5Hz conditions. There was no significant inter-hemispheric difference in response.These results suggest that short trains of high and low frequency rTMS delivered to prefrontal cortex evoke a differential HbO response and provide additional evidence that high frequency trains result in increased neural activity. The findings may provide further explanation for the improved symptoms observed in MDD patients treated with high frequency rTMS.

UR - http://www.brainstimjrnl.com/article/S1935-861X(15)00595-1/abstract

U2 - 10.1016/j.brs.2015.01.171

DO - 10.1016/j.brs.2015.01.171

M3 - Abstract

SP - 364

T2 - International Brain Stimulation Conference 2015

Y2 - 2 March 2015 through 4 March 2015

ER -

A near infra-red study of blood oxygenation changes resulting from high and low frequency repetitive transcranial magnetic stimulation

Abstract

Conference

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