A near infra-red study of blood oxygenation changes resulting from high and low frequency repetitive transcranial magnetic stimulation

Ting T. Cao, Richard H. Thomson, Neil W. Bailey, Nigel C. Rogasch, Rebecca A. Segrave, Jerome J. Maller, Zafiris J. Daskalakis, Paul B. Fitzgerald

Research output: Contribution to conferenceAbstractpeer-review


High and low frequency repetitive transcranial magnetic stimulation (rTMS) are both used to treat major depressive disorder (MDD). However, the physiological mechanisms underlying the therapeutic benefit and the effect of the stimulation frequency are unclear.

Twelve healthy participants received 1Hz, 2Hz and 5Hz active rTMS. Twenty 5 second trains were delivered at left dorsolateral prefrontal cortex at 110% of resting motor threshold with a 25 second inter-train interval.

Blood oxygenation (HbO) was significantly reduced following the 1Hz trains compared to the HbO increases observed in both the 2Hz and 5Hz conditions. There was no significant inter-hemispheric difference in response.

These results suggest that short trains of high and low frequency rTMS delivered to prefrontal cortex evoke a differential HbO response and provide additional evidence that high frequency trains result in increased neural activity. The findings may provide further explanation for the improved symptoms observed in MDD patients treated with high frequency rTMS.
Original languageEnglish
Number of pages1
Publication statusPublished - 2015
Event1st International Brain Stimulation Conference - Singapore Expo Convention and Exhibition Centre, Singapore, Singapore
Duration: 2 Mar 20154 Mar 2015
Conference number: 1


Conference1st International Brain Stimulation Conference
Internet address

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