A near infra-red study of blood oxygenation changes resulting from high and low frequency repetitive transcranial magnetic stimulation

Research output: Contribution to journalArticleResearchpeer-review

Abstract

High and low frequency repetitive transcranial magnetic stimulation (rTMS) are both used to treat major depressive disorder(MDD). However, the physiological mechanisms underlying the therapeutic benefit and the effect of the stimulation frequency are unclear. Twelve healthy participants received 1Hz, 2Hz, and 5Hz active rTMS. Twenty 5 second trains were delivered at left dorsolateral prefrontal cortex at 110 of resting motor threshold with a 25 second inter-train interval. Blood oxygenation (HbO) was significantly reduced following the 1Hz trains compared to the HbO increases observed in both the 2Hz and 5Hz conditions. There was no significant inter-hemispheric difference in response. These results suggest that short trains of high and low frequency rTMS delivered to prefrontal cortex evoke a differential HbO response and provide additional evidence that high frequency trains result in increased neural activity. The findings may provide further explanation for the improved symptoms observed in MDD patients treated with high frequency rTMS. ? 2013 Elsevier Inc. All rights reserved.
Original languageEnglish
Pages (from-to)922 - 924
Number of pages3
JournalBrain Stimulation
Volume6
Issue number6
DOIs
Publication statusPublished - 2013

Cite this

@article{ec88552e40814f878fa3f86eac61bc19,
title = "A near infra-red study of blood oxygenation changes resulting from high and low frequency repetitive transcranial magnetic stimulation",
abstract = "High and low frequency repetitive transcranial magnetic stimulation (rTMS) are both used to treat major depressive disorder(MDD). However, the physiological mechanisms underlying the therapeutic benefit and the effect of the stimulation frequency are unclear. Twelve healthy participants received 1Hz, 2Hz, and 5Hz active rTMS. Twenty 5 second trains were delivered at left dorsolateral prefrontal cortex at 110 of resting motor threshold with a 25 second inter-train interval. Blood oxygenation (HbO) was significantly reduced following the 1Hz trains compared to the HbO increases observed in both the 2Hz and 5Hz conditions. There was no significant inter-hemispheric difference in response. These results suggest that short trains of high and low frequency rTMS delivered to prefrontal cortex evoke a differential HbO response and provide additional evidence that high frequency trains result in increased neural activity. The findings may provide further explanation for the improved symptoms observed in MDD patients treated with high frequency rTMS. ? 2013 Elsevier Inc. All rights reserved.",
author = "Cao, {Ting Ting} and Thomson, {Richard Hilton Siddall} and Neil Bailey and Nigel Rogasch and Segrave, {Rebecca Anne} and Maller, {Jerome Joseph} and Daskalakis, {Zafiris Jeff} and Fitzgerald, {Paul Bernard}",
year = "2013",
doi = "10.1016/j.brs.2013.04.006",
language = "English",
volume = "6",
pages = "922 -- 924",
journal = "Brain Stimulation",
issn = "1935-861X",
publisher = "Elsevier",
number = "6",

}

TY - JOUR

T1 - A near infra-red study of blood oxygenation changes resulting from high and low frequency repetitive transcranial magnetic stimulation

AU - Cao, Ting Ting

AU - Thomson, Richard Hilton Siddall

AU - Bailey, Neil

AU - Rogasch, Nigel

AU - Segrave, Rebecca Anne

AU - Maller, Jerome Joseph

AU - Daskalakis, Zafiris Jeff

AU - Fitzgerald, Paul Bernard

PY - 2013

Y1 - 2013

N2 - High and low frequency repetitive transcranial magnetic stimulation (rTMS) are both used to treat major depressive disorder(MDD). However, the physiological mechanisms underlying the therapeutic benefit and the effect of the stimulation frequency are unclear. Twelve healthy participants received 1Hz, 2Hz, and 5Hz active rTMS. Twenty 5 second trains were delivered at left dorsolateral prefrontal cortex at 110 of resting motor threshold with a 25 second inter-train interval. Blood oxygenation (HbO) was significantly reduced following the 1Hz trains compared to the HbO increases observed in both the 2Hz and 5Hz conditions. There was no significant inter-hemispheric difference in response. These results suggest that short trains of high and low frequency rTMS delivered to prefrontal cortex evoke a differential HbO response and provide additional evidence that high frequency trains result in increased neural activity. The findings may provide further explanation for the improved symptoms observed in MDD patients treated with high frequency rTMS. ? 2013 Elsevier Inc. All rights reserved.

AB - High and low frequency repetitive transcranial magnetic stimulation (rTMS) are both used to treat major depressive disorder(MDD). However, the physiological mechanisms underlying the therapeutic benefit and the effect of the stimulation frequency are unclear. Twelve healthy participants received 1Hz, 2Hz, and 5Hz active rTMS. Twenty 5 second trains were delivered at left dorsolateral prefrontal cortex at 110 of resting motor threshold with a 25 second inter-train interval. Blood oxygenation (HbO) was significantly reduced following the 1Hz trains compared to the HbO increases observed in both the 2Hz and 5Hz conditions. There was no significant inter-hemispheric difference in response. These results suggest that short trains of high and low frequency rTMS delivered to prefrontal cortex evoke a differential HbO response and provide additional evidence that high frequency trains result in increased neural activity. The findings may provide further explanation for the improved symptoms observed in MDD patients treated with high frequency rTMS. ? 2013 Elsevier Inc. All rights reserved.

UR - http://www.ncbi.nlm.nih.gov/pubmed/23721908

U2 - 10.1016/j.brs.2013.04.006

DO - 10.1016/j.brs.2013.04.006

M3 - Article

VL - 6

SP - 922

EP - 924

JO - Brain Stimulation

JF - Brain Stimulation

SN - 1935-861X

IS - 6

ER -