TY - JOUR
T1 - A near infra-red study of blood oxygenation changes resulting from high and low frequency repetitive transcranial magnetic stimulation
AU - Cao, Ting Ting
AU - Thomson, Richard Hilton Siddall
AU - Bailey, Neil
AU - Rogasch, Nigel
AU - Segrave, Rebecca Anne
AU - Maller, Jerome Joseph
AU - Daskalakis, Zafiris Jeff
AU - Fitzgerald, Paul Bernard
PY - 2013
Y1 - 2013
N2 - High and low frequency repetitive transcranial magnetic stimulation (rTMS) are both used to treat major depressive disorder(MDD). However, the physiological mechanisms underlying the therapeutic benefit and the effect of the stimulation frequency are unclear. Twelve healthy participants received 1Hz, 2Hz, and 5Hz active rTMS. Twenty 5 second trains were delivered at left dorsolateral prefrontal cortex at 110 of resting motor threshold with a 25 second inter-train interval. Blood oxygenation (HbO) was significantly reduced following the 1Hz trains compared to the HbO increases observed in both the 2Hz and 5Hz conditions. There was no significant inter-hemispheric difference in response. These results suggest that short trains of high and low frequency rTMS delivered to prefrontal cortex evoke a differential HbO response and provide additional evidence that high frequency trains result in increased neural activity. The findings may provide further explanation for the improved symptoms observed in MDD patients treated with high frequency rTMS. ? 2013 Elsevier Inc. All rights reserved.
AB - High and low frequency repetitive transcranial magnetic stimulation (rTMS) are both used to treat major depressive disorder(MDD). However, the physiological mechanisms underlying the therapeutic benefit and the effect of the stimulation frequency are unclear. Twelve healthy participants received 1Hz, 2Hz, and 5Hz active rTMS. Twenty 5 second trains were delivered at left dorsolateral prefrontal cortex at 110 of resting motor threshold with a 25 second inter-train interval. Blood oxygenation (HbO) was significantly reduced following the 1Hz trains compared to the HbO increases observed in both the 2Hz and 5Hz conditions. There was no significant inter-hemispheric difference in response. These results suggest that short trains of high and low frequency rTMS delivered to prefrontal cortex evoke a differential HbO response and provide additional evidence that high frequency trains result in increased neural activity. The findings may provide further explanation for the improved symptoms observed in MDD patients treated with high frequency rTMS. ? 2013 Elsevier Inc. All rights reserved.
UR - http://www.ncbi.nlm.nih.gov/pubmed/23721908
U2 - 10.1016/j.brs.2013.04.006
DO - 10.1016/j.brs.2013.04.006
M3 - Article
SN - 1935-861X
VL - 6
SP - 922
EP - 924
JO - Brain Stimulation
JF - Brain Stimulation
IS - 6
ER -