A multifunctional biomimetic hybrid nanocarrier for the controlled delivery of chemotherapy drugs by near-infrared light

Xinyu Cui, Wenlong Cheng, Mingdong Dong, Xiaojun Han

Research output: Contribution to journalArticleResearchpeer-review

4 Citations (Scopus)

Abstract

Controlled drug release is a promising technique that is used in the treatment of cancer. Herein, drug nanocarriers were developed based on Fe 3 O 4 @mSiO 2 (mesoporous silica-coated Fe 3 O 4 ) nanoparticles (NPs) gated by a lipid bilayer. The nanocarriers exhibited near-infrared (NIR) light-stimulated drug release in a remote and stepwise pattern. Mesoporous silica surrounds Fe 3 O 4 NPs and ensures high drug capacity and easy modification of the lipid bilayer. Heat generated from the Fe 3 O 4 NPs upon NIR irradiations increases the permeability of the lipid bilayer, which in turn causes drug release. Based on in vitro experiment results, DOX-loaded nanocarriers exhibited the highest cell death percentage of 75.7% with NIR laser irradiation for 5 min at the doxorubicin (DOX) dose of 10 μg mL −1 . Because of the flexible and precise control of NIR laser, the nanocarriers have great potential in cancer treatment.

Original languageEnglish
Pages (from-to)2752-2757
Number of pages6
JournalNew Journal of Chemistry
Volume43
Issue number6
DOIs
Publication statusPublished - 1 Jan 2019

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