Abstract
Controlled drug release is a promising technique that is used in the treatment of cancer. Herein, drug nanocarriers were developed based on Fe 3 O 4 @mSiO 2 (mesoporous silica-coated Fe 3 O 4 ) nanoparticles (NPs) gated by a lipid bilayer. The nanocarriers exhibited near-infrared (NIR) light-stimulated drug release in a remote and stepwise pattern. Mesoporous silica surrounds Fe 3 O 4 NPs and ensures high drug capacity and easy modification of the lipid bilayer. Heat generated from the Fe 3 O 4 NPs upon NIR irradiations increases the permeability of the lipid bilayer, which in turn causes drug release. Based on in vitro experiment results, DOX-loaded nanocarriers exhibited the highest cell death percentage of 75.7% with NIR laser irradiation for 5 min at the doxorubicin (DOX) dose of 10 μg mL −1 . Because of the flexible and precise control of NIR laser, the nanocarriers have great potential in cancer treatment.
Original language | English |
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Pages (from-to) | 2752-2757 |
Number of pages | 6 |
Journal | New Journal of Chemistry |
Volume | 43 |
Issue number | 6 |
DOIs | |
Publication status | Published - 1 Jan 2019 |